Tenofovir disoproxil fumarate

🧮 Dose calculator

Chronic hepatitis B · Regimen source: FDA Viread · 2.2, Table 1

• • With or without food. Same dose for HIV. Before starting test for HIV and HBV; creatinine, CrCl, urine glucose and protein. CrCl 30–49: every 48 h; 10–29: every 72–96 h; haemodialysis: weekly after dialysis. FDA Viread · 2.2FDA Viread · 2.4FDA Viread · 2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Viread · 8.1

  “Risk Summary Available data from the APR show no increase in the overall risk of major birth defects with first trimester exposure for tenofovir disoproxil fumarate (TDF) (2.1%) compared with the background rate for major birth defects of 2.7% in a U.S. reference population of the Metropolitan Atlanta Congenital …”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Viread · 8.2

  “Risk Summary Based on published data, tenofovir has been shown to be present in human breast milk (see Data ).”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Viread · 8.4

  “Safety and effectiveness of VIREAD in pediatric patients younger than 2 years of age and weighing less than 10 kg with HIV-1 infection have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Viread · 8.5

  “In general, dose selection for the elderly patient should be cautious, keeping in mind the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.