Tacrolimus (oral)

🧮 Dose calculator

Prevention of organ transplant rejection · Regimen source: FDA Prograf · 2.2, Table 1

• • Initial dose; then adjust by whole-blood trough levels per the table. First dose for liver/heart/lung no sooner than 6 h after transplant. Avoid grapefruit. FDA Prograf · 2.2, Table 1FDA Prograf · 2.2FDA Prograf · 2.1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Prograf · 8.1

  “Risk Summary Tacrolimus can cause fetal harm when administered to a pregnant woman.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Prograf · 8.2

  “Risk Summary Controlled lactation studies have not been conducted in humans; however, tacrolimus has been reported to be present in human milk.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Prograf · 8.4

  “Safety and effectiveness have been established in pediatric liver, kidney, heart, and lung transplant patients.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Prograf · 8.5

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Prograf · 8.3

  “Contraception PROGRAF can cause fetal harm when administered to pregnant women.”