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Prevention of organ transplant rejection
Prevention of organ transplant rejection · ICD-10: T86.10
Symptoms
- • Declining function of the transplanted organ
- • General discomfort or ill feeling
- • Pain or swelling over the organ (rare), fever (rare)
- • Flu-like symptoms: chills, body aches, nausea, cough, shortness of breath
- • Kidney: less urine; heart: heart-failure symptoms
Drugs and regimens
Cyclosporine (oral, modified)⚠ Unverified
Organ transplant — initial dose by organ and protocol (mean 7–9 mg/kg/day)
Mycophenolate mofetil⚠ Unverified
Kidney transplant — adult 1 g twice daily
Mycophenolate mofetil⚠ Unverified
Heart or liver transplant — adult 1.5 g twice daily
Mycophenolate mofetil⚠ Unverified
Pediatric kidney transplant (≥3 months) — 600 mg/m² twice daily (max 2 g/day)
Tacrolimus (oral)⚠ Unverified
Kidney transplant with MMF or IL-2RA — 0.1 mg/kg/day in two doses every 12 h
Tacrolimus (oral)⚠ Unverified
Kidney transplant with azathioprine — 0.2 mg/kg/day in two doses
Tacrolimus (oral)⚠ Unverified
Liver transplant — 0.1–0.15 mg/kg/day in two doses
Tacrolimus (oral)⚠ Unverified
Heart transplant — 0.075 mg/kg/day in two doses