Propafenone

🧮 Dose calculator

Atrial fibrillation / anticoagulation · Regimen source: FDA Propafenone · 2

• • 150 mg every 8 h; after at least 3–4 days to 225 then 300 mg every 8 h. Not with structural heart disease. FDA Propafenone · 2

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Propafenone · 8.1

  “Risk Summary There are no studies of propafenone hydrochloride in pregnant women.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Propafenone · 8.2

  “Risk Summary Propafenone and its active metabolite, 5-OH-propafenone, are present in human milk, but the levels are likely to be low.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Propafenone · 8.4

  “The safety and effectiveness of propafenone in pediatric patients have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Propafenone · 8.5

  “In general, dose selection for an elderly patients should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Propafenone · 8.3

  “Infertility Males: Based on human and animal studies, propafenone hydrochloride may transiently impair spermatogenesis in males.”