Piperacillin-tazobactam
پیپراسیلین-تازوباکتام
🦠 Antiinfectives For Systemic UsePenicillin + beta-lactamase inhibitor
Market / country: 🇺🇸 USA
Zosyn (US)
🧮 Dose calculator
Complicated intra-abdominal infection and peritonitis · Regimen source: FDA Pip-tazo · 2.1
- • Dose as total piperacillin + tazobactam; 30-min infusion. 40.5 g bottle is a pharmacy bulk package (single-dose 2.25/3.375/4.5 g also exist). FDA Pip-tazo · 2FDA Pip-tazo · 3
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ History of allergic reaction to penicillins, cephalosporins or beta-lactamase inhibitors. FDA Pip-tazo · 4
Warnings
- • Serious hypersensitivity; Clostridioides difficile-associated diarrhoea; seizures (especially with renal impairment). FDA Pip-tazo · 5
Renal adjustment
- • eGFR < 40: CrCl 20–40 and <20: reduce per label table. FDA Pip-tazo · 2.3
Formulations
- 40.5 g pharmacy bulk bottle (36 g piperacillin + 4.5 g tazobactam) — powder for injection 🇺🇸 USA FDA Pip-tazo · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Pip-tazo · 8.1
“Risk Summary Piperacillin and tazobactam cross the placenta in humans.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Pip-tazo · 8.2
“Risk Summary Piperacillin is excreted in human milk; tazobactam concentrations in human milk have not been studied.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Pip-tazo · 8.4
“The safety and effectiveness of piperacillin and tazobactam for injection for intra-abdominal infections, and nosocomial pneumonia have been established in pediatric patients 2 months of age and older.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Pip-tazo · 8.5
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA203720
- DailyMed (FDA label)FDA Pip-tazo
- MedlinePlus (NIH)Piperacillin and Tazobactam Injection
- WHO ATC/DDDJ01CR05
- Darooyab (Iran)❌ None
🇮🇷 Not found in Iran list Darooyab · search
Darooyab lists no registered dosage form or brand for this drug. This does not prove it is unavailable.
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Pip-tazo · 3FDA Pip-tazo · 2.1FDA Pip-tazo · 2FDA Pip-tazo · 2.2FDA Pip-tazo · 2.4FDA Pip-tazo · 4FDA Pip-tazo · 5FDA Pip-tazo · 2.3FDA Pip-tazo · 8.1FDA Pip-tazo · 8.2FDA Pip-tazo · 8.4FDA Pip-tazo · 8.5FDA Pip-tazo · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · search
- Clinical review⚠ Unverified