Piperacillin-tazobactam

پیپراسیلین-تازوباکتام

⚠ Unverified

🦠 Antiinfectives For Systemic UsePenicillin + beta-lactamase inhibitor

Market / country: 🇺🇸 USA

Zosyn (US)

🧮 Dose calculator

Complicated intra-abdominal infection and peritonitis · Regimen source: FDA Pip-tazo · 2.1

  • • Dose as total piperacillin + tazobactam; 30-min infusion. 40.5 g bottle is a pharmacy bulk package (single-dose 2.25/3.375/4.5 g also exist). FDA Pip-tazo · 2FDA Pip-tazo · 3

Enter age (weight is optional for this regimen).

🛡️ Safety & information

Contraindications

  • ⛔ History of allergic reaction to penicillins, cephalosporins or beta-lactamase inhibitors. FDA Pip-tazo · 4

Warnings

  • • Serious hypersensitivity; Clostridioides difficile-associated diarrhoea; seizures (especially with renal impairment). FDA Pip-tazo · 5

Renal adjustment

Formulations

  • 40.5 g pharmacy bulk bottle (36 g piperacillin + 4.5 g tazobactam) — powder for injection 🇺🇸 USA FDA Pip-tazo · 3

👥 Special populations

  • 🤰 PregnancyUse with caution

    Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Pip-tazo · 8.1

    “Risk Summary Piperacillin and tazobactam cross the placenta in humans.”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Pip-tazo · 8.2

    “Risk Summary Piperacillin is excreted in human milk; tazobactam concentrations in human milk have not been studied.”
  • 👶 ChildrenUse with caution

    The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Pip-tazo · 8.4

    “The safety and effectiveness of piperacillin and tazobactam for injection for intra-abdominal infections, and nosocomial pneumonia have been established in pediatric patients 2 months of age and older.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Pip-tazo · 8.5

    “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”
  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

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Doz is only a support tool and does not replace clinical judgment or official sources. Check every dose against the original source before prescribing. About & disclaimer · Sources

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