Pasireotide

🧮 Dose calculator

Cushing disease · Regimen source: FDA Signifor · 2.1

• • Range 0.3–0.9 mg twice daily; titrate by urinary free cortisol. Before starting: FPG, HbA1c, liver tests, ECG, gallbladder ultrasound, potassium and magnesium. Child-Pugh B: start 0.3, max 0.6 mg twice daily; avoid in Child-Pugh C. FDA Signifor · 2.1FDA Signifor · 2.2FDA Signifor · 2.3

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Signifor · 8.1

  “Risk Summary The limited data with SIGNIFOR in pregnant women are insufficient to inform a drug-associated risk for major birth defects and miscarriage.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Signifor · 8.2

  “Risk Summary There is no information available on the presence of SIGNIFOR in human milk, the effects of the drug on the breastfed infant, or the effects of the drug on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Signifor · 8.4

  “Safety and effectiveness of SIGNIFOR have not been established in pediatric patients.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Signifor · 8.5

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant disease or other drug therapy [see Clinical Pharmacology (12.3)] .”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Signifor · 8.3

  “… zation of serum cortisol levels in female patients with Cushing's disease treated with pasireotide may lead to improved fertility.”