Paricalcitol
پاریکلسیتول
🧬 Systemic Hormonal Preparations, Excl. Sex Hormones And InsulinsActive vitamin D analogue
Market / country: 🇺🇸 USA
Zemplar (US)
🧮 Dose calculator
Secondary hyperparathyroidism in chronic kidney disease · Regimen source: FDA Zemplar injection · 2.2
- • Calcium must not be above normal before starting. Calcium twice weekly and PTH every 2–4 weeks; titrate per Table 1. Max 0.24 mcg/kg. FDA Zemplar injection · 2.1FDA Zemplar injection · 2.2
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Hypercalcaemia; vitamin D toxicity; hypersensitivity to paricalcitol. FDA Zemplar injection · 4
Warnings
- • Hypercalcaemia; digitalis toxicity potentiated by hypercalcaemia; adynamic bone disease with PTH over-suppression. FDA Zemplar injection · 5
Formulations
- 5 mcg/mL vial — injection 🇺🇸 USA FDA Zemplar injection · 3
- 2 mcg/mL vial — injection 🇺🇸 USA FDA Zemplar injection · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Zemplar injection · 8.1
“Risk Summary Limited data with ZEMPLAR in pregnant women are insufficient to inform a drug-associated risk for major birth defects and miscarriage.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Zemplar injection · 8.2
“Risk Summary There is no information available on the presence of paricalcitol in human milk, the effects of the drug on the breastfed infant or the effects of the drug on milk production.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Zemplar injection · 8.4
“The safety and efficacy of ZEMPLAR for the prevention and treatment of secondary hyperparathyroidism associated with CKD have been established in pediatric patients 5 years of age and older with CKD on dialysis.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Zemplar injection · 8.5
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA020819
- DailyMed (FDA label)FDA Zemplar injection
- MedlinePlus (NIH)❌ None
- WHO ATC/DDDH05BX02
- Darooyab (Iran)❌ None
🇮🇷 Not found in Iran list Darooyab · search
Darooyab lists no registered dosage form or brand for this drug. This does not prove it is unavailable.
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Zemplar injection · 3FDA Zemplar injection · 2.2FDA Zemplar injection · 2.1FDA Zemplar injection · 4FDA Zemplar injection · 5FDA Zemplar injection · SPL approval / marketing categoryFDA Zemplar injection · 8.1FDA Zemplar injection · 8.2FDA Zemplar injection · 8.4FDA Zemplar injection · 8.5
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · search
- Clinical review⚠ Unverified