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Ondansetron

اندانسترون

⚠ Unverified

🩺 Gastrointestinal5-HT3 receptor antagonist

Market / country: 🇺🇸 USA

Zofran (US)

🧮 Dose calculator

Disease / regimen

Vomiting due to acute gastroenteritis · Regimen source: CPS Ondansetron 2018 · Recommendations

• Single dose only; no benefit from multiple doses. Start oral rehydration 15–30 min later. For mild–moderate dehydration or failed ORS; not routine when moderate–severe diarrhea predominates. CPS Ondansetron 2018 · Recommendations
• Weight-band alternative: 8–15 kg 2 mg; 15–30 kg 4 mg; >30 kg 6–8 mg. Liquid form recommended; a 4 mg tablet cannot give doses below 4 mg. CPS Ondansetron 2018 · Recommendations
• This use is not in the FDA label (label: chemotherapy and postoperative nausea prevention). FDA Ondansetron · 1

Formulation

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🛡️ Safety & information

Contraindications

⛔ Hypersensitivity (e.g. anaphylaxis) to ondansetron. FDA Ondansetron · 4
⛔ Concomitant apomorphine (profound hypotension, loss of consciousness). FDA Ondansetron · 4

Warnings

• QT prolongation FDA Ondansetron · 5.2
• Serotonin syndrome FDA Ondansetron · 5.3
• Myocardial ischemia FDA Ondansetron · 5.4
• May mask progressive ileus and gastric distension FDA Ondansetron · 5.5
• Routine ECG/electrolyte screening before a single oral dose is not supported in children without known risk factors. CPS Ondansetron 2018 · Recommendations

Formulations

4 mg tablet — tablet 🇺🇸 USA FDA Ondansetron · 3
8 mg tablet — tablet 🇺🇸 USA FDA Ondansetron · 3
4 mg orally disintegrating tablet — orally disintegrating tablet 🇺🇸 USA FDA Ondansetron · 2.1

📚 Reference status for this drug

Shows which sources have references recorded for this drug and which do not.

FDA label (DailyMed)✅ Present
FDA Ondansetron · 3 FDA Ondansetron · 2.1 FDA Ondansetron · 1 FDA Ondansetron · 2.1, Table 2 FDA Ondansetron · 8.4 FDA Ondansetron · 2.1, Table 1 FDA Ondansetron · 4 FDA Ondansetron · 5.2 FDA Ondansetron · 5.3 FDA Ondansetron · 5.4 FDA Ondansetron · 5.5
UK SmPC (eMC / MHRA)❌ Not present
Published guideline✅ Present
CPS Ondansetron 2018 · Recommendations
Licensed reference (medical school)❌ Not present
Iranian leaflet (IFDA)❌ Not present
Clinical review⚠ Unverified

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