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Sodium nitroprusside
سدیم نیتروپروساید
❤️ Cardiovascular SystemDirect vasodilator
🤰 Pregnancy:Use with caution🤱 Breastfeeding:Use with caution👶 Children:Use with caution 🇮🇷 Registered in Iran⛔ 1 contraindications 🇺🇸 FDA approved (NDA) NDA209387ATC C02DD01
Market / country: 🇺🇸 USA
Nipride RTU (US)
🧮 Dose calculator
Hypertensive emergency (hospital) · Regimen source: FDA Nipride RTU · 2.2
- • Continuous BP monitoring; wait ≥5 min before changing. Volumetric pump only. Do not use blue, green or bright-red solution. At the maximum rate, cyanide buffering capacity is exceeded in under 1 h. FDA Nipride RTU · 2.2FDA Nipride RTU · 2.3FDA Nipride RTU · 2.1FDA Nipride RTU · Boxed Warning
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Compensatory hypertension (aortic coarctation, AV shunting); inadequate cerebral circulation or moribund patients (ASA 5E); Leber’s optic atrophy or tobacco amblyopia; acute heart failure with reduced peripheral resistance; sildenafil, tadalafil, vardenafil or riociguat. FDA Nipride RTU · 4
Warnings
- • Boxed warning: precipitous hypotension (ischaemic injury or death); dose-related, potentially lethal cyanide toxicity — limit time at the maximum rate. FDA Nipride RTU · Boxed Warning
Formulations
- 0.2 mg/mL ready-to-use (= 200 mcg/mL) — injection 🇺🇸 USA FDA Nipride RTU · 3
- 0.5 mg/mL ready-to-use (= 500 mcg/mL) — injection 🇺🇸 USA FDA Nipride RTU · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Nipride RTU · 8.1
“Risk Summary Based on animal data and mechanism of action, sodium nitroprusside may lead to cyanide exposure and potential adverse effects in the fetus [see Clinical Pharmacology ( 12.3 ) and Clinical Considerations] .”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Nipride RTU · 8.2
“Risk Summary There is no information about the presence of sodium nitroprusside in human milk, the effects on the breastfed infant, or the effects on milk production.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Nipride RTU · 8.4
“Efficacy in the pediatric population was established based on adult trials and supported by the dose-ranging trial (Study 1) and an open label trial of at least 12 hour infusion at a rate that achieved adequate MAP control (Study 2) with pediatric patients on sodium nitroprusside.”
- 👴 Older adultsNo data
The source for this drug has no section for this group.
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA209387
- DailyMed (FDA label)FDA Nipride RTU
- MedlinePlus (NIH)❌ None
- WHO ATC/DDDC02DD01
- Darooyab (Iran)Sodium-Nitroprusside
🇮🇷 Registered in Iran Darooyab · G-1884/Sodium-Nitroprusside
Dosage forms with Iranian generic codes, per Darooyab.
- 00916 · NITROPRUSSIDE SODIUM 50MG AMP · آمپول نیتروپروسساید سدیم ۵۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Nipride RTU · 3FDA Nipride RTU · 2.2FDA Nipride RTU · 2.3FDA Nipride RTU · 2.1FDA Nipride RTU · Boxed WarningFDA Nipride RTU · 4FDA Nipride RTU · SPL approval / marketing categoryFDA Nipride RTU · 8.1FDA Nipride RTU · 8.2FDA Nipride RTU · 8.4
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-1884/Sodium-Nitroprusside
- Clinical review⚠ Unverified