Sodium nitroprusside

سدیم نیتروپروساید

⚠ Unverified

❤️ Cardiovascular SystemDirect vasodilator

Market / country: 🇺🇸 USA

Nipride RTU (US)

🧮 Dose calculator

Hypertensive emergency (hospital) · Regimen source: FDA Nipride RTU · 2.2

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🛡️ Safety & information

Contraindications

  • ⛔ Compensatory hypertension (aortic coarctation, AV shunting); inadequate cerebral circulation or moribund patients (ASA 5E); Leber’s optic atrophy or tobacco amblyopia; acute heart failure with reduced peripheral resistance; sildenafil, tadalafil, vardenafil or riociguat. FDA Nipride RTU · 4

Warnings

  • • Boxed warning: precipitous hypotension (ischaemic injury or death); dose-related, potentially lethal cyanide toxicity — limit time at the maximum rate. FDA Nipride RTU · Boxed Warning

Formulations

👥 Special populations

  • 🤰 PregnancyUse with caution

    Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Nipride RTU · 8.1

    “Risk Summary Based on animal data and mechanism of action, sodium nitroprusside may lead to cyanide exposure and potential adverse effects in the fetus [see Clinical Pharmacology ( 12.3 ) and Clinical Considerations] .”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Nipride RTU · 8.2

    “Risk Summary There is no information about the presence of sodium nitroprusside in human milk, the effects on the breastfed infant, or the effects on milk production.”
  • 👶 ChildrenUse with caution

    The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Nipride RTU · 8.4

    “Efficacy in the pediatric population was established based on adult trials and supported by the dose-ranging trial (Study 1) and an open label trial of at least 12 hour infusion at a rate that achieved adequate MAP control (Study 2) with pediatric patients on sodium nitroprusside.”
  • 👴 Older adultsNo data

    The source for this drug has no section for this group.

  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

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