Nicardipine (IV)
نیکاردیپین وریدی
❤️ Cardiovascular SystemDihydropyridine calcium channel blocker
Market / country: 🇺🇸 USA
Cardene IV (US)
🧮 Dose calculator
Hypertensive emergency (hospital) · Regimen source: FDA Cardene IV · 2.1
- • Start 5 mg/h; increase by 2.5 mg/h every 5–15 min to max 15 mg/h. The calculator shows bag mL/h. Central or large peripheral vein; change peripheral site every 12 h. FDA Cardene IV · 2.1FDA Cardene IV · 2.3
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Advanced aortic stenosis. FDA Cardene IV · 4
Warnings
- • Monitor closely in angina, heart failure, hepatic or renal impairment; avoid small hand/wrist veins (thrombosis, phlebitis); avoid intra-arterial injection or extravasation. FDA Cardene IV · 5
Formulations
- 20 mg/200 mL premixed (0.1 mg/mL) — injection 🇺🇸 USA FDA Cardene IV · 3
- 40 mg/200 mL premixed (0.2 mg/mL) — injection 🇺🇸 USA FDA Cardene IV · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Cardene IV · 8.1
“Risk Summary Available data from published literature (clinical trials and case series) over decades of use of intravenous nicardipine during pregnancy have not identified a drug-associated risk of major birth defects or miscarriage.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Cardene IV · 8.2
“Risk Summary Nicardipine is present in human milk in low amounts.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Cardene IV · 8.4
“The safety and effectiveness of CARDENE I.V. have not been established in pediatric patients.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Cardene IV · 8.5
“The steady-state pharmacokinetics of nicardipine are similar in elderly hypertensive patients (>65 years) and young healthy adults.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA019734
- DailyMed (FDA label)FDA Cardene IV
- MedlinePlus (NIH)Nicardipine
- WHO ATC/DDDC08CA04
- Darooyab (Iran)Nicardipine
🇮🇷 Registered in Iran Darooyab · G-1790/Nicardipine
Dosage forms with Iranian generic codes, per Darooyab.
- 52516 · NICARDIPINE HYDROCHLORIDE CAPSULE ORAL 20 mg · کپسول نیکاردیپین هیدروکلراید ۲۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Cardene IV · 3FDA Cardene IV · 2.1FDA Cardene IV · 2.3FDA Cardene IV · 4FDA Cardene IV · 5FDA Cardene IV · SPL approval / marketing categoryFDA Cardene IV · 8.1FDA Cardene IV · 8.2FDA Cardene IV · 8.4FDA Cardene IV · 8.5
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-1790/Nicardipine
- Clinical review⚠ Unverified