Nirmatrelvir + ritonavir

🧮 Dose calculator

COVID-19 · Regimen source: FDA Paxlovid · 2.2

• • Each dose: 2 nirmatrelvir tablets + 1 ritonavir tablet together. eGFR 30–60: 150 mg + 100 mg twice daily. eGFR <30: day 1 300 + 100 once, days 2–5 150 + 100 once daily. Not recommended in severe hepatic impairment. FDA Paxlovid · 2.2FDA Paxlovid · 2.3, Table 1FDA Paxlovid · 2.4

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Paxlovid · 8.1

  “Risk Summary Available data on the use of nirmatrelvir during pregnancy are insufficient to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Paxlovid · 8.2

  “Risk Summary Nirmatrelvir and ritonavir are present in human breast milk in small amounts (less than 2%).”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Paxlovid · 8.4

  “The optimal dose of PAXLOVID has not been established in pediatric patients.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Paxlovid · 8.5

  “Clinical studies of PAXLOVID include subjects 65 years of age and older and their data contributes to the overall assessment of safety and efficacy [see Adverse Reactions (6.1) and Clinical Studies (14.1) ] .”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Paxlovid · 8.3

  “Contraception Use of ritonavir may reduce the efficacy of combined hormonal contraceptives.”