Isotretinoin

🧮 Dose calculator

Severe recalcitrant nodular acne · Regimen source: FDA Zenatane · 2.1

• • Adults with very severe disease up to 2 mg/kg/day. Only within the iPLEDGE programme (US). FDA Zenatane · 2.1FDA Zenatane · 5.2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyContraindicated

  Label: contraindicated in pregnancy. FDA Zenatane · 4

  “Zenatane is contraindicated in: Pregnancy [see Warnings and Precautions ( 5.1 ) and Use in Specific Populations ( 8.1 )].”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Zenatane · 8.2

  “Because of the potential for serious adverse reactions in nursing infants from isotretinoin, advise patients that breastfeeding is not recommended during treatment with Zenatane, and for at least 8 days after the last dose of Zenatane.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Zenatane · 8.4

  “The safety and effectiveness of Zenatane for the treatment of severe recalcitrant nodular acne have been established in non-pregnant pediatric patients 12 years of age and older with multiple inflammatory nodules with a diameter of 5 mm or greater who are unresponsive to conventional treatment, including systemic …”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Zenatane · 8.5

  “Clinical studies of Zenatane did not include sufficient numbers of patients 65 years of age and older to determine whether they respond differently from younger adult patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Zenatane · 8.3

  “… of Zenatane treatment, AND (2) after the patient has used their chosen pregnancy prevention methods (i.e., two forms of contraception or committed to abstinence) for at least 30 days.”