Interferon beta-1a (IM)
اینترفرون بتا-۱a (عضلانی)
🎗️ Antineoplastic And Immunomodulating AgentsInterferon
Market / country: 🇺🇸 USA
Avonex (US)
🧮 Dose calculator
Multiple sclerosis (relapsing) · Regimen source: FDA Avonex · 2.1
- • To reduce flu-like symptoms: start 7.5 mcg and increase by 7.5 mcg weekly over 3 weeks. Analgesic/antipyretic on injection days. FDA Avonex · 2.1FDA Avonex · 2.3
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to natural or recombinant interferon beta. FDA Avonex · 4
Warnings
- • Depression, suicide and psychosis; hepatic injury; anaphylaxis; injection-site necrosis; heart failure; decreased blood counts; thrombotic microangiopathy; seizures. FDA Avonex · 5
Formulations
- 30 mcg/0.5 mL prefilled syringe or autoinjector — injection 🇺🇸 USA FDA Avonex · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Avonex · 8.1
“Risk Summary Data from a large population-based cohort study, as well as other published studies over several decades, have not identified a drug-associated risk of major birth defects with the use of interferon beta products during early pregnancy.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Avonex · 8.2
“Risk Summary Limited published literature has described the presence of interferon beta-1a products in human milk at low levels.”
- 👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Avonex · 8.4
“Safety and effectiveness in pediatric patients have not been established.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Avonex · 8.5
“Clinical studies of AVONEX did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)BLA103628
- DailyMed (FDA label)FDA Avonex
- MedlinePlus (NIH)Interferon Beta-1a Intramuscular InjectionInterferon Beta-1a Subcutaneous Injection
- WHO ATC/DDDL03AB07
- Darooyab (Iran)Interferon-Beta-1A
🇮🇷 Registered in Iran Darooyab · G-4579/Interferon-Beta-1A
Dosage forms with Iranian generic codes, per Darooyab.
- 22378 · INTERFERON B 1A 30 MCG PREFILLED SYRINGE · سرنگ از پیش پرشده اینترفرون B ۱ A ۳۰ میکروگرم
- 02667 · INTERFERON B 1A 30 MCG VIAL · ویال اینترفرون B ۱ A ۳۰ میکروگرم
- 02666 · INTERFERON BETA-1A INJECTION PARENTERAL 12000000 [iU] 0.5MILLILITER · فرآورده تزریقی اینترفرون بتا–۱ A ۱۲۰۰۰۰۰۰ واحد بینالمللی ۰٫۵ میلیلیتر
- 51988 · INTERFERON BETA-1A INJECTION PARENTERAL 12000000 [iU]/1mL 0.5MILLILITER · فرآورده تزریقی اینترفرون بتا–۱ A ۱۲۰۰۰۰۰۰ واحد بینالمللی / ۱ میلیلیتر ۰٫۵ میلیلیتر
- 52034 · INTERFERON BETA-1A INJECTION PARENTERAL 12000000 [iU] 1.5MILLILITER · فرآورده تزریقی اینترفرون بتا–۱ A ۱۲۰۰۰۰۰۰ واحد بینالمللی ۱٫۵ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Avonex · 3FDA Avonex · 2.1FDA Avonex · 2.3FDA Avonex · 4FDA Avonex · 5FDA Avonex · SPL approval / marketing categoryFDA Avonex · 8.1FDA Avonex · 8.2FDA Avonex · 8.4FDA Avonex · 8.5
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-4579/Interferon-Beta-1A
- Clinical review⚠ Unverified