Antihemophilic factor VIII (recombinant)

🧮 Dose calculator

Haemophilia A · Regimen source: FDA Advate · 2.1

• • Bleeding or surgery: dose (IU) = weight (kg) × desired FVIII rise (%) × 0.5; frequency by bleed type. Or every third day targeting trough ≥1%. FDA Advate · 2.1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Advate · 8.1

  “Risk Summary There are no data with ADVATE use in pregnant women to inform a drug-associated risk.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Advate · 8.2

  “Risk Summary There is no information regarding the presence of ADVATE in human milk, the effect on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Advate · 8.4

  “Pharmacokinetic studies in children have demonstrated higher clearance, a shorter half-life and lower recovery of factor VIII compared to adults [see Clinical Pharmacology (12.3) ] .”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Advate · 8.5

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease and other drug therapy.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.