Dornase alfa

🧮 Dose calculator

Cystic fibrosis · Regimen source: FDA Pulmozyme · 2.1

• • Some patients may benefit from twice daily. Do not mix with other drugs in the nebulizer. FDA Pulmozyme · 2.1FDA Pulmozyme · 2.2

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Pulmozyme · 8.1

  “Risk Summary There are no adequate and well-controlled studies with PULMOZYME in pregnant women.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Pulmozyme · 8.2

  “In a pharmacokinetic study in Cynomolgus monkeys, levels of dornase alfa detected in milk were less than 0.1% of the maternal serum concentration at 24 hours after dosing [intravenous bolus dose (0.1 mg/kg) of dornase alfa followed by an intravenous infusion (0.080 mg/kg/hr) over a 6-hour period] on post-partum day 14.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Pulmozyme · 8.4

  “The safety and effectiveness of PULMOZYME in conjunction with standard therapies for cystic fibrosis have been established in pediatric patients.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Pulmozyme · 8.5

  “Cystic fibrosis is primarily a disease of children and young adults.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.