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Amoxicillin-clavulanate (co-amoxiclav)

کوآموکسی‌کلاو (آموکسی‌سیلین/کلاوولانیک اسید)

⚠ Unverified

💊 AntibioticsAminopenicillin + beta-lactamase inhibitor

Market / country: 🇺🇸 USA

Augmentin (US) · Augmentin ES-600 (US)

🧮 Dose calculator

Disease / regimen

Acute otitis media · Regimen source: FDA Augmentin · 2.2, Table 1

• Dose is calculated on the amoxicillin component. FDA Augmentin · 2.2
• Duration studied and recommended for acute otitis media is 10 days. FDA Augmentin · 2.2, Table 1, footnote b
• The every-12-hour regimen is recommended (significantly less diarrhea). 200 and 400 mg/5 mL products contain aspartame (phenylketonurics). FDA Augmentin · 2.2

Formulation

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🛡️ Safety & information

Contraindications

⛔ History of serious hypersensitivity to amoxicillin/clavulanate or other beta-lactams. FDA Augmentin ES-600 · 4.1 FDA Augmentin · 4
⛔ History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate. FDA Augmentin ES-600 · 4.2 FDA Augmentin · 4

Warnings

• Hypersensitivity reactions FDA Augmentin · 5.1
• Hepatic dysfunction FDA Augmentin · 5.2
• Clostridium difficile-associated diarrhea FDA Augmentin · 5.3
• Skin rash in patients with mononucleosis FDA Augmentin · 5.4
• Phenylketonurics: some products contain aspartame FDA Augmentin · 5.6
• 250/125 mg tablet is not interchangeable with 250/62.5 mg chewable; do not use until the child weighs at least 40 kg. FDA Augmentin · 2.2

Renal adjustment

• eGFR < 30: GFR <30 mL/min: do not give the 875 mg dose; adjust per label. FDA Augmentin · 2.3

Formulations

125/31.25 mg per 5 mL (4:1) — suspension 🇺🇸 USA FDA Augmentin · 3
250/62.5 mg per 5 mL (4:1) — suspension 🇺🇸 USA FDA Augmentin · 3
200/28.5 mg per 5 mL (7:1) — suspension 🇺🇸 USA FDA Augmentin · 3
400/57 mg per 5 mL (7:1) — suspension 🇺🇸 USA FDA Augmentin · 3
ES-600: 600/42.9 mg per 5 mL (14:1) — suspension 🇺🇸 USA FDA Augmentin ES-600 · 3
500/125 mg tablet — tablet 🇺🇸 USA FDA Augmentin · 3
875/125 mg tablet (scored) — tablet 🇺🇸 USA FDA Augmentin · 3

📚 Reference status for this drug

Shows which sources have references recorded for this drug and which do not.

FDA label (DailyMed)✅ Present
FDA Augmentin · 3 FDA Augmentin ES-600 · 3 FDA Augmentin · 2.2, Table 1 FDA Augmentin · 2.2 FDA Augmentin · 2.2, Table 1, footnote b FDA Augmentin ES-600 · 2.2, Table 1 FDA Augmentin ES-600 · 8.4 FDA Augmentin ES-600 · 2.2 FDA Augmentin ES-600 · 2.6 FDA Augmentin · 2.1 FDA Augmentin ES-600 · 4.1 FDA Augmentin · 4 FDA Augmentin ES-600 · 4.2 FDA Augmentin · 5.1 FDA Augmentin · 5.2 FDA Augmentin · 5.3 FDA Augmentin · 5.4 FDA Augmentin · 5.6 FDA Augmentin · 2.3
UK SmPC (eMC / MHRA)❌ Not present
Published guideline❌ Not present
Licensed reference (medical school)❌ Not present
Iranian leaflet (IFDA)❌ Not present
Clinical review⚠ Unverified

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