Amifampridine

🧮 Dose calculator

Lambert-Eaton myasthenic syndrome · Regimen source: FDA Firdapse · 2.1, Table 1

• • Start 15–30 mg/day in 3–5 doses. Max single dose 20 mg. Renal or hepatic impairment and NAT2 poor metabolizers: lowest starting dose (15 mg). FDA Firdapse · 2.1, Table 1FDA Firdapse · 2.2FDA Firdapse · 2.3FDA Firdapse · 2.4

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👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Firdapse · 8.1

  “Risk Summary There are no data on the developmental risk associated with the use of FIRDAPSE in pregnant women.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Firdapse · 8.2

  “Risk Summary There are no data on the presence of FIRDAPSE in human milk, the effects on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Firdapse · 8.4

  “Safety and effectiveness of FIRDAPSE for the treatment of LEMS have been established in pediatric patients 6 years of age and older.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Firdapse · 8.5

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy [see Dosage and Administration ( 2.2 , 2.3 ) and Drug …”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.