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Lambert-Eaton myasthenic syndrome

Lambert-Eaton myasthenic syndrome · ICD-10: G73.1

Symptoms

  • • Weakness mostly in the legs; trouble climbing stairs and standing up
  • • Weakness may improve briefly after exercise
  • • Head drooping, trouble chewing, swallowing and talking
  • • Blurred or double vision
  • • Dry mouth and eyes, constipation, reduced sweating, dizziness on standing, erectile dysfunction

MedlinePlus · Symptoms

Drugs and regimens

Amifampridine⚠ Unverified

LEMS — adults and children ≥45 kg: start 15 mg/day in 3 doses, +5 mg every 3–4 days (max 100 mg/day)

Amifampridine⚠ Unverified

LEMS — child ≥6 y under 45 kg: start 5–15 mg/day in 3–5 doses (max 50 mg/day)

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