Pyrimethamine

🧮 Dose calculator

Toxoplasmosis · Regimen source: FDA Daraprim · Dosage and Administration

• • With 1–4 g of a sulfonamide (e.g. sulfadiazine) daily and folinic acid (leucovorin) in all patients. Then about half the dose for 4–5 weeks. Children: 1 mg/kg/day in two doses for 2–4 days, then half for about a month. FDA Daraprim · Dosage and Administration

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Daraprim · Precautions/Warnings – Pregnancy

  “DARAPRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Daraprim · Precautions/Warnings – Nursing Mothers

  “… rimethamine and from concurrent use of a sulfonamide with DARAPRIM for treatment of some patients with toxoplasmosis, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother (see WARNINGS and PRECAUTIONS:”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Daraprim · Precautions/Warnings – Pediatric Use

  “See DOSAGE AND ADMINISTRATION section.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Daraprim · Precautions/Warnings – Geriatric Use

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.