Pralidoxime

🧮 Dose calculator

Organophosphate or muscarinic mushroom poisoning · Regimen source: FDA Protopam · Dosage and Administration — Adult intravenous dosing

• • After atropine (correct hypoxia first). In 100 mL saline over 15–30 min; max 200 mg/min. If weakness persists, second dose after about 1 h, then every 10–12 h. Little benefit beyond 36 h after exposure ends; observe 48–72 h. FDA Protopam · Dosage and Administration

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Protopam · Pregnancy

  “Teratogenic Effects: Animal reproduction studies have not been conducted with pralidoxime chloride.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Protopam · Nursing Mothers

  “Because many drugs are excreted in human milk, caution should be exercised when pralidoxime chloride is administered to a nursing woman.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Protopam · Pediatric Use

  “There are no adequate and well-controlled clinical trials that establish the effectiveness of pralidoxime chloride in pediatric patients.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Protopam · Geriatric Use

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.