Penicillin G benzathine + procaine
پنیسیلین بنزاتین + پروکائین
🦠 Antiinfectives For Systemic UseLong-acting IM penicillin
Market / country: 🇺🇸 USA
Bicillin C-R (US)
🧮 Dose calculator
Scarlet fever and erysipelas (group A streptococcus) · Regimen source: FDA Bicillin C-R · Dosage and Administration — Streptococcal Infections
- • Label in pounds: <30 lb → 600,000; 30–60 lb → 900,000–1,200,000; >60 lb → 2,400,000 units (converted to kg). Deep IM only. FDA Bicillin C-R · Dosage and Administration — Streptococcal Infections
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to penicillin or procaine. FDA Bicillin C-R · Contraindications
Warnings
- • Warning: never inject intravenously — cardiorespiratory arrest and death reported. FDA Bicillin C-R · Warnings
Formulations
- 1,200,000 units / 2 mL syringe (deep IM only) — injection 🇺🇸 USA FDA Bicillin C-R · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Bicillin C-R · Pregnancy
“Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Bicillin C-R · Nursing Mothers
“Caution should be exercised when penicillin G benzathine and penicillin G procaine are administered to a nursing woman.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Bicillin C-R · Pediatric Use
“(See INDICATIONS AND USAGE and DOSAGE AND ADMINISTRATION sections.)”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Bicillin C-R · Geriatric use
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA050138
- DailyMed (FDA label)FDA Bicillin C-R
- MedlinePlus (NIH)❌ None
- WHO ATC/DDDJ01CE30
- Darooyab (Iran)Procaine-Penicillin-G
🇮🇷 Registered in Iran Darooyab · G-484/Procaine-Penicillin-G
Dosage forms with Iranian generic codes, per Darooyab.
- 01863 · PENICILLIN G PROCAINE 1,000,000 U VIAL · ویال پنیسیلین گرم پروکائین ۱۰۰۰۰۰۰ واحد
- 00961 · PENICILLIN G PROCAINE 400,000 U VIAL · ویال پنیسیلین گرم پروکائین ۴۰۰۰۰۰ واحد
- 00962 · PENICILLIN G PROCAINE 800,000 U VIAL · ویال پنیسیلین گرم پروکائین ۸۰۰۰۰۰ واحد
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Bicillin C-R · How SuppliedFDA Bicillin C-R · Dosage and Administration — Streptococcal InfectionsFDA Bicillin C-R · ContraindicationsFDA Bicillin C-R · WarningsFDA Bicillin C-R · SPL approval / marketing categoryFDA Bicillin C-R · PregnancyFDA Bicillin C-R · Nursing MothersFDA Bicillin C-R · Pediatric UseFDA Bicillin C-R · Geriatric use
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-484/Procaine-Penicillin-G
- Clinical review⚠ Unverified