Doz

Penicillamine

پنی‌سیلامین

⚠ Unverified

🦴 Musculo-Skeletal SystemChelating agent (copper, cystine)

🤰 Pregnancy:Contraindicated🤱 Breastfeeding:Use with caution👶 Children:Use with caution👴 Older adults:Use with caution 🇮🇷 Registered in Iran⛔ 1 contraindications 🇺🇸 FDA approved (NDA) NDA019853ATC M01CC01

Market / country: 🇺🇸 USA

Cuprimine (US)

🧮 Dose calculator

Wilson disease · Regimen source: FDA Cuprimine · Dosage and Administration

⛔ Titrated to urinary copper excretion and free serum copper. On an empty stomach (1 h before or 2 h after food), apart from other drugs and milk. Pyridoxine supplement may be needed. FDA Cuprimine · Dosage and Administration

🛡️ Safety & information

Contraindications

  • ⛔ Pregnancy (except Wilson disease or some cystinuria); breastfeeding; prior penicillamine-related aplastic anaemia or agranulocytosis; rheumatoid arthritis with history or evidence of renal insufficiency. FDA Cuprimine · Contraindications

Warnings

  • • Fatalities from aplastic anaemia, agranulocytosis, thrombocytopenia, Goodpasture syndrome and myasthenia gravis — urinalysis and CBC twice weekly initially. FDA Cuprimine · Warnings

Formulations

👥 Special populations

  • 🤰 PregnancyContraindicated

    Label: contraindicated in pregnancy. FDA Cuprimine · CONTRAINDICATIONS

    “Except for the treatment of Wilson’s disease or certain patients with cystinuria, use of penicillamine during pregnancy is contraindicated (see WARNINGS ).”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Cuprimine · Nursing Mothers

    “See CONTRAINDICATIONS .”
  • 👶 ChildrenUse with caution

    The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Cuprimine · Pediatric Use

    “The efficacy of CUPRIMINE in juvenile rheumatoid arthritis has not been established.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Cuprimine · Geriatric Use

    “In general, dose selection for an elderly patient should be cautious, starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drugs.”
  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

📚 Reference status for this drug

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