Miltefosine

🧮 Dose calculator

Cutaneous leishmaniasis · Regimen source: FDA Impavido · 2, Table 1

• • With food. Label-approved species for cutaneous disease: L. braziliensis, L. guyanensis, L. panamensis; the species common in Iran (L. major, L. tropica) are not in the label. FDA Impavido · 2, Table 1FDA Impavido · 1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyContraindicated

  Label: contraindicated in pregnancy. FDA Impavido · 4

  “IMPAVIDO is contraindicated in pregnant women.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Impavido · 8.3

  “Because many drugs are present in human milk and because of the potential for serious adverse reactions in nursing infants from IMPAVIDO, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Impavido · 8.4

  “Safety and effectiveness in pediatric patients < 12 years have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Impavido · 8.5

  “Clinical studies of IMPAVIDO did not include sufficient numbers of subjects 65 years of age and over to determine if they respond differently than younger subjects.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Impavido · 8.8

  “Contraception IMPAVIDO may cause fetal harm when used during pregnancy.”