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Meropenem-vaborbactam

مروپنم-واباربکتام

⚠ Unverified

🦠 Antiinfectives For Systemic UseCarbapenem + beta-lactamase inhibitor

🤰 Pregnancy:Use with caution 🤱 Breastfeeding:Use with caution 👶 Children:Safety not established 👴 Older adults:Use with caution ⚥ Females & males of reproductive potential:Use with caution 🇮🇷 Not found in Iran list ⛔ 1 contraindications 🇺🇸 FDA approved (NDA) NDA209776 ATC J01DH52

Market / country: 🇺🇸 USA

Vabomere (US)

🧮 Dose calculator

Disease / regimen

Urinary tract infection · Regimen source: FDA Vabomere · 2.1

• Dose as total meropenem + vaborbactam (2 vials). Compatible only with 0.9% sodium chloride. FDA Vabomere · 2.1 FDA Vabomere · 2.4

Formulation

Age *

Weight (kg) (optional)

Enter age (weight is optional for this regimen).

🛡️ Safety & information

Contraindications

⛔ Hypersensitivity to meropenem, vaborbactam or same-class drugs; anaphylaxis with beta-lactams. FDA Vabomere · 4

Warnings

• Hypersensitivity; seizures; reduced valproic acid levels with breakthrough seizures; thrombocytopenia; C. difficile diarrhoea; rhabdomyolysis. FDA Vabomere · 5

Renal adjustment

• eGFR < 50: eGFR <50: 30–49 → 2 g every 8 h; 15–29 → 2 g every 12 h; <15 → 1 g every 12 h; haemodialysis: after dialysis. FDA Vabomere · 2.2, Table 1

Formulations

2 g vial (meropenem 1 g + vaborbactam 1 g) — powder for injection 🇺🇸 USA FDA Vabomere · 3

👥 Special populations

🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Vabomere · 8.1
“Risk Summary Fetal malformations were observed in vaborbactam-treated rabbits, therefore advise pregnant women of the potential risks to the fetus.”
🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Vabomere · 8.2
“Meropenem has been reported to be excreted in human milk.”
👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Vabomere · 8.4
“The safety and effectiveness of VABOMERE in pediatric patients (younger than 18 years of age) has not been established.”
👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Vabomere · 8.5
“Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.”
⚥ Females & males of reproductive potentialUse with caution
Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Vabomere · 8.3
“Use of VABOMERE may reduce the effectiveness of hormonal contraceptives.”

🔗 Reference links

FDA (approval record)NDA209776
DailyMed (FDA label)FDA Vabomere
MedlinePlus (NIH)Meropenem and Vaborbactam Injection
WHO ATC/DDDJ01DH52
Darooyab (Iran)❌ None

🇮🇷 Not found in Iran list Darooyab · search

Darooyab lists no registered dosage form or brand for this drug. This does not prove it is unavailable.

📚 Reference status for this drug

Shows which sources have references recorded for this drug and which do not.

FDA label (DailyMed)✅ Present
FDA Vabomere · 3 FDA Vabomere · 2.1 FDA Vabomere · 2.4 FDA Vabomere · 4 FDA Vabomere · 5 FDA Vabomere · 2.2, Table 1 FDA Vabomere · SPL approval / marketing category FDA Vabomere · 8.1 FDA Vabomere · 8.2 FDA Vabomere · 8.4 FDA Vabomere · 8.5 FDA Vabomere · 8.3
UK SmPC (eMC / MHRA)❌ Not present
Published guideline❌ Not present
Licensed reference (medical school)❌ Not present
Iranian leaflet (IFDA)❌ Not present
Pharmacy website (secondary, unreliable)✅ Present
Darooyab · search
Clinical review⚠ Unverified

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