Hydroxyurea

🧮 Dose calculator

Sickle cell anaemia · Regimen source: FDA Siklos · 2.1, Table 1

• • Use actual or ideal weight, whichever is less. Blood count every 2 weeks; increase 5 mg/kg every 8 weeks up to 35 mg/kg. CrCl <60: half dose. FDA Siklos · 2.1, Table 1FDA Siklos · 2.2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Siklos · 8.1

  “Risk Summary SIKLOS can cause fetal harm based on findings from animal studies and the drug's mechanism of action [see Clinical Pharmacology (12.1) ] .”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Siklos · 8.2

  “Because of the potential for serious adverse reactions in a breastfed child from SIKLOS, including carcinogenicity, advise patients not to breastfeed during treatment with SIKLOS.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Siklos · 8.4

  “The safety and effectiveness of SIKLOS have been established in pediatric patients aged 2-18 years with sickle cell anemia with recurrent moderate to severe painful crises.”

• 👴 Older adultsNo data

  The source for this drug has no section for this group.

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Siklos · 8.3

  “Contraception Females Advise females of reproductive potential to use effective contraception during and after treatment with SIKLOS for at least 6 months after therapy.”