Fosphenytoin (injection)

🧮 Dose calculator

Status epilepticus / acute repetitive seizures · Regimen source: FDA Cerebyx · 2.3FDA Cerebyx · Highlights — Dosage and Administration

• • All doses in phenytoin sodium equivalents (PE). Rate: adults 100–150 mg PE/min (max 150); children 2 mg PE/kg/min or 150 mg PE/min, whichever is slower. Dilute to 1.5–25 mg PE/mL before infusion. Continuous ECG, BP and respiratory monitoring. Usually with an IV benzodiazepine; follow with maintenance dosing. FDA Cerebyx · 2.3FDA Cerebyx · 2.2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Cerebyx · 8.1

  “Risk Summary In humans, prenatal exposure to phenytoin (the active metabolite of CEREBYX) may increase the risks for congenital malformations and other adverse developmental outcomes.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Cerebyx · 8.2

  “Following administration of phenytoin (the active metabolite of CEREBYX), phenytoin is secreted in human milk.”

• 👶 ChildrenUse with caution

  Label: indicated in all pediatric age groups; pediatric infusion rate max 2 mg PE/kg/min or 150 mg PE/min, whichever is slower. FDA Cerebyx · 8.4

  “CEREBYX is indicated for the treatment of generalized tonic-clonic status epilepticus and prevention and treatment of seizures occurring during neurosurgery in all pediatric age groups”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Cerebyx · 8.5

  “No systematic studies in geriatric patients have been conducted.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.