Doxylamine + pyridoxine
دوکسیلامین + پیریدوکسین (تهوع بارداری)
🫁 Respiratory SystemAntihistamine + vitamin B6
Market / country: 🇺🇸 USA
Diclegis (US) · Xonvea (GB)
🧮 Dose calculator
Nausea and vomiting of pregnancy · Regimen source: FDA Diclegis · 2.1
- • If not enough: from day 3 one in the morning + 2 at bedtime; max 4 tablets (1 morning, 1 mid-afternoon, 2 bedtime). Swallow whole. FDA Diclegis · 2.1
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to doxylamine or pyridoxine; MAO inhibitors. FDA Diclegis · 4
Warnings
- • Drowsiness — do not drive; worse with alcohol and sedatives. FDA Diclegis · 5
Formulations
- Doxylamine 10 mg + pyridoxine 10 mg delayed-release tablet — tablet 🇺🇸 USA FDA Diclegis · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Diclegis · 8.1
“Risk Summary DICLEGIS is intended for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Diclegis · 8.2
“Women should not breastfeed while using DICLEGIS.”
- 👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Diclegis · 8.4
“The safety and effectiveness of DICLEGIS in children under 18 years of age have not been established.”
- 👴 Older adultsNo data
The source for this drug has no section for this group.
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA021876
- DailyMed (FDA label)FDA Diclegis
- MedlinePlus (NIH)Doxylamine and Pyridoxine
- WHO ATC/DDDR06AA59
- Darooyab (Iran)❌ None
🇮🇷 Not found in Iran list Darooyab · search
Darooyab lists no registered dosage form or brand for this drug. This does not prove it is unavailable.
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Diclegis · 3FDA Diclegis · 2.1FDA Diclegis · 4FDA Diclegis · 5FDA Diclegis · 8.1FDA Diclegis · 8.2FDA Diclegis · 8.4FDA Diclegis · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · search
- Clinical review⚠ Unverified