Disulfiram
دیسولفیرام
🧠 Nervous SystemAlcohol deterrent
Market / country: 🇺🇸 USA
Antabuse (US)
🧮 Dose calculator
Alcohol dependence · Regimen source: FDA Disulfiram · Dosage and Administration
- • Only after at least 12 h of abstinence and with the patient’s full knowledge. FDA Disulfiram · Dosage and AdministrationFDA Disulfiram · Boxed Warning
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Recent metronidazole, paraldehyde, alcohol or alcohol-containing preparations; severe myocardial disease or coronary occlusion; psychosis; thiuram hypersensitivity. FDA Disulfiram · Contraindications
Warnings
- • Boxed warning: never give to an intoxicated patient or without their knowledge. Hepatitis and hepatic failure (sometimes fatal); optic neuritis and neuropathy. FDA Disulfiram · Boxed WarningFDA Disulfiram · Warnings
Important interactions
- • Metronidazole and alcohol-containing preparations (cough syrups, tonics) — contraindicated. FDA Disulfiram · Contraindications
Formulations
- 250 mg tablet — tablet 🇺🇸 USA FDA Disulfiram · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Darooyab: category C — only if benefit outweighs risk. Darooyab · G-3801/Disulfiram — مصرف در بارداری
“مصرف در بارداری دی سولفیرام گروه C در شرايط خاص و نظارت ويژه پزشك قابل استفاده است:”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Disulfiram · Nursing Mothers
“Since many drugs are so excreted, disulfiram should not be given to nursing mothers.”
- 👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Disulfiram · Pediatric Use
“Safety and effectiveness in pediatric patients have not been established.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Disulfiram · Geriatric Use
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA091681
- DailyMed (FDA label)FDA Disulfiram
- MedlinePlus (NIH)Disulfiram
- WHO ATC/DDDN07BB01
- Darooyab (Iran)Disulfiram
🇮🇷 Registered in Iran Darooyab · G-3801/Disulfiram
Dosage forms with Iranian generic codes, per Darooyab.
- 06745 · DISULFIRAM 200MG TAB · قرص دیسولفیرام ۲۰۰ میلیگرم
- 08634 · DISULFIRAM 250MG TAB · قرص دیسولفیرام ۲۵۰ میلیگرم
- 08106 · DISULFIRAM 500MG TAB · قرص دیسولفیرام ۵۰۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Disulfiram · How SuppliedFDA Disulfiram · Dosage and AdministrationFDA Disulfiram · Boxed WarningFDA Disulfiram · ContraindicationsFDA Disulfiram · WarningsFDA Disulfiram · SPL approval / marketing categoryFDA Disulfiram · Nursing MothersFDA Disulfiram · Pediatric UseFDA Disulfiram · Geriatric Use
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-3801/DisulfiramDarooyab · G-3801/Disulfiram — مصرف در بارداری
- Clinical review⚠ Unverified