Diphenhydramine (injection)
دیفنهیدرامین (تزریقی)
🫁 Respiratory SystemFirst-generation antihistamine
Market / country: 🇺🇸 USA
Benadryl injection (US)
🧮 Dose calculator
Acute allergic reaction (adjunct to epinephrine) · Regimen source: FDA Diphenhydramine inj. · Dosage and Administration — Adults
- • 100 mg if required; max 400 mg/day; IV no faster than 25 mg/min. FDA Diphenhydramine inj. · Dosage and Administration — Adults
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Neonates and premature infants. FDA Diphenhydramine inj. · Contraindications
- ⚠️ Nursing mothers. FDA Diphenhydramine inj. · Contraindications
- ⛔ Hypersensitivity to diphenhydramine. FDA Diphenhydramine inj. · Contraindications
Formulations
- 50 mg/mL vial — injection 🇺🇸 USA FDA Diphenhydramine inj. · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Diphenhydramine inj. · Pregnancy
“Teratogenic Effects—Pregnancy Category B Reproduction studies have been performed in rats and rabbits at doses up to 5 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to diphenhydramine hydrochloride.”
- 🤱 BreastfeedingContraindicated
Label: contraindicated while breastfeeding. FDA Diphenhydramine inj. · CONTRAINDICATIONS
“Use in Nursing Mothers Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Diphenhydramine inj. · Pediatric Use
“Diphenhydramine should not be used in neonates and premature infants (see CONTRAINDICATIONS ).”
- 👴 Older adultsNo data
The source for this drug has no section for this group.
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA080817
- DailyMed (FDA label)FDA Diphenhydramine inj.
- MedlinePlus (NIH)DiphenhydramineDiphenhydramine Injection
- WHO ATC/DDDR06AA02
- Darooyab (Iran)Diphenhydramine
🇮🇷 Registered in Iran Darooyab · G-792/Diphenhydramine
Dosage forms with Iranian generic codes, per Darooyab.
- 18777 · DIPHENHYDRAMINE 25MG SOFT GEL CAP · کپسول نرم دیفنهیدرامین ۲۵ میلیگرم
- 00454 · DIPHENHYDRAMINE HCL 12.5MG/5ML 60ML ELIXIR · الگزیر دیفنهیدرامین هیدروکلراید ۱۲٫۵ میلیگرم / ۵ میلیلیتر ۶۰ میلیلیتر
- 12558 · DIPHENHYDRAMINE HCL 20MG/2ML INJ · فرآورده تزریقی دیفنهیدرامین هیدروکلراید ۲۰ میلیگرم / ۲ میلیلیتر
- 00455 · DIPHENHYDRAMINE HCL 25MG TAB · قرص دیفنهیدرامین هیدروکلراید ۲۵ میلیگرم
- 01475 · DIPHENHYDRAMINE HCL 50MG TAB · قرص دیفنهیدرامین هیدروکلراید ۵۰ میلیگرم
- 00453 · DIPHENHYDRAMINE HCL 50MG/1ML AMP · آمپول دیفنهیدرامین هیدروکلراید ۵۰ میلیگرم / ۱ میلیلیتر
- 51885 · DIPHENHYDRAMINE HYDROCHLORIDE SOLUTION ORAL 12.5 mg/5mL 120 mL · محلول خوراکی دیفنهیدرامین هیدروکلراید ۱۲٫۵ میلیگرم / ۵ میلیلیتر ۱۲۰ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Diphenhydramine inj. · How SuppliedFDA Diphenhydramine inj. · Dosage and Administration — AdultsFDA Diphenhydramine inj. · Dosage and Administration — Pediatric PatientsFDA Diphenhydramine inj. · ContraindicationsFDA Diphenhydramine inj. · PregnancyFDA Diphenhydramine inj. · CONTRAINDICATIONSFDA Diphenhydramine inj. · Pediatric UseFDA Diphenhydramine inj. · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-792/Diphenhydramine
- Clinical review⚠ Unverified