Buprenorphine + naloxone (sublingual)

🧮 Dose calculator

Opioid use disorder · Regimen source: FDA Buprenorphine-nalox. · 2.3

• • Shown as the buprenorphine component. After induction with sublingual buprenorphine; adjust in 2 or 4 mg steps; usual range 4–24 mg/day. Under the tongue until dissolved; do not chew or swallow. Start with supervised dosing. FDA Buprenorphine-nalox. · 2.3FDA Buprenorphine-nalox. · 2.1FDA Buprenorphine-nalox. · 2.4FDA Buprenorphine-nalox. · 2.5

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Buprenorphine-nalox. · 8.1

  “Risk Summary The data on use of buprenorphine, one of the active ingredients in Buprenorphine and Naloxone Sublingual Tablets, in pregnancy, are limited; however, these data do not indicate an increased risk of major malformations specifically due to buprenorphine exposure.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Buprenorphine-nalox. · 8.2

  “Risk Summary Based on two studies in 13 lactating women maintained on buprenorphine treatment, buprenorphine and its metabolite norbuprenorphine were present in low levels in human milk and available data have not shown adverse reactions in breastfed infants.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Buprenorphine-nalox. · 8.4

  “The safety and effectiveness of Buprenorphine and Naloxone Sublingual Tablets have not been established in pediatric patients.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Buprenorphine-nalox. · 8.5

  “… g therapy in geriatric patients, the decision to prescribe Buprenorphine and Naloxone Sublingual Tablets should be made cautiously in individuals 65 years of age or older and these patients should be monitored for signs and symptoms of toxicity or overdose.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Buprenorphine-nalox. · 8.3

  “Infertility Chronic use of opioids may cause reduced fertility in females and males of reproductive potential.”