Bupivacaine
بوپیواکائین (مارکائین)
🧠 Nervous SystemLong-acting amide local anaesthetic
Market / country: 🇺🇸 USA
Marcaine / Sensorcaine (US)
🧮 Dose calculator
Spinal and epidural anaesthesia · Regimen source: FDA Marcaine Spinal · 2.2
- • Smallest effective dose and concentration. Only by experienced clinicians with resuscitation available. FDA Marcaine Spinal · 2.2
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Obstetric paracervical block (fetal bradycardia and death); IV regional anaesthesia (Bier block); hypersensitivity to amide local anaesthetics. Spinal: septicaemia, severe haemorrhage, shock, significant arrhythmia, local infection. FDA Marcaine · 4FDA Marcaine Spinal · 4
Warnings
- • Systemic toxicity (seizures, cardiac arrest) with intravascular injection; have resuscitation ready. FDA Marcaine · 5
Formulations
- Spinal 0.75% in 8.25% dextrose — 15 mg/2 mL (7.5 mg/mL) — injection 🇺🇸 USA FDA Marcaine Spinal · 3
- 0.25% (2.5 mg/mL) — injection 🇺🇸 USA FDA Marcaine · 3
- 0.5% (5 mg/mL) — injection 🇺🇸 USA FDA Marcaine · 3
- 0.75% (7.5 mg/mL) — injection 🇺🇸 USA FDA Marcaine · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Marcaine Spinal · 8.1
“Risk Summary The available data on the use of MARCAINE SPINAL in pregnant women do not establish the presence or absence of developmental toxicity related to the use of MARCAINE SPINAL.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Marcaine Spinal · 8.2
“Risk Summary Lactation studies have not been conducted with bupivacaine.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Marcaine Spinal · 8.4
“MARCAINE SPINAL is approved for use in adults only.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Marcaine Spinal · 8.5
“Patients 65 years and over, particularly those with hypertension, may be at increased risk for developing hypotension while undergoing spinal anesthesia with MARCAINE SPINAL.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA018692
- DailyMed (FDA label)FDA Marcaine SpinalFDA Marcaine
- MedlinePlus (NIH)Bupivacaine InjectionBupivacaine Liposomal Injection
- WHO ATC/DDDN01BB01
- Darooyab (Iran)Bupivacaine
🇮🇷 Registered in Iran Darooyab · G-2748/Bupivacaine
Dosage forms with Iranian generic codes, per Darooyab.
- 02316 · BUPIVACAINE HCL 0.25% 10ML VIAL · ویال بوپیواکائین هیدروکلراید ۰٫۲۵ درصد ۱۰ میلیلیتر
- 00181 · BUPIVACAINE HCL 0.25% 20ML VIAL · ویال بوپیواکائین هیدروکلراید ۰٫۲۵ درصد ۲۰ میلیلیتر
- 00182 · BUPIVACAINE HCL 0.5% 10ML VIAL · ویال بوپیواکائین هیدروکلراید ۰٫۵ درصد ۱۰ میلیلیتر
- 02317 · BUPIVACAINE HCL 0.5% 20ML VIAL · ویال بوپیواکائین هیدروکلراید ۰٫۵ درصد ۲۰ میلیلیتر
- 01413 · BUPIVACAINE HCL 0.5% 4ML SPINAL INJ · فرآورده تزریقی بوپیواکائین هیدروکلراید ۰٫۵ درصد ۴ میلیلیتر سپینال
- 16649 · BUPIVACAINE/EPINEPHRINE 5/500MG/ML CARTRIDGE · کارتریج بوپیواکائین / اپینفرین ۵ / ۵۰۰ میلیگرم / میلیلیتر
- 51847 · BUPIVACAINE HYDROCHLORIDE INJECTION PARENTERAL 0.5 % 10 mL · فرآورده تزریقی بوپیواکائین هیدروکلراید ۰٫۵ درصد ۱۰ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Marcaine Spinal · 3FDA Marcaine · 3FDA Marcaine Spinal · 2.2FDA Marcaine · 2.2FDA Marcaine · 2.3FDA Marcaine · 4FDA Marcaine Spinal · 4FDA Marcaine · 5FDA Marcaine Spinal · SPL approval / marketing categoryFDA Marcaine Spinal · 8.1FDA Marcaine Spinal · 8.2FDA Marcaine Spinal · 8.4FDA Marcaine Spinal · 8.5
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-2748/Bupivacaine
- Clinical review⚠ Unverified