Artemether + lumefantrine

🧮 Dose calculator

Malaria (prophylaxis and treatment) · Regimen source: FDA Coartem · 2.2–2.3

• • Shown as the artemether component (20 mg per tablet). First dose, second dose after 8 h, then twice daily for the next 2 days (6 doses total). Take with food; repeat a dose vomited within 1–2 h. FDA Coartem · 2.2–2.3FDA Coartem · 2.1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Coartem · 8.1

  “Risk Summary Published data from clinical studies and pharmacovigilance data have not established an association with artemether/lumefantrine use during pregnancy and major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data) .”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Coartem · 8.2

  “Risk Summary There are no data on the presence of artemether or lumefantrine in human milk, the effects on the breastfed infant or the effects on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Coartem · 8.4

  “The safety and effectiveness of Coartem Tablets have been established in pediatric patients aged 2 months and older with a bodyweight of 5 kg and above for the treatment of acute, uncomplicated malaria [see Clinical Studies (14.1)] .”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Coartem · 8.5

  “Clinical studies of Coartem Tablets did not include sufficient numbers of subjects aged 65 years and over to determine whether they respond differently from younger subjects.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Coartem · 8.3

  “Contraception Use of Coartem may reduce the efficacy of hormonal contraceptives.”