Ambrisentan

🧮 Dose calculator

Pulmonary arterial hypertension (PAH) · Regimen source: FDA Letairis · 2.1

• • Titrate at 4-week intervals. Do not split, crush or chew. FDA Letairis · 2.1

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyContraindicated

  Label: contraindicated in pregnancy. FDA Letairis · 4

  “Letairis is contraindicated in females who are pregnant.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Letairis · 8.2

  “Because many drugs are present in human milk and because of the potential for serious adverse reactions in breastfed infants from Letairis, a decision should be made whether to discontinue breastfeeding or discontinue Letairis, taking into account the importance of the drug to the mother.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Letairis · 8.4

  “Safety and effectiveness of Letairis in pediatric patients have not been established .”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Letairis · 8.5

  “The elderly (age ≥65 years) showed less improvement in walk distances with Letairis than younger patients did, but the results of such subgroup analyses must be interpreted cautiously.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Letairis · 8.3

  “Contraception Patients who can become pregnant who are using ambrisentan should use effective contraception prior to initiation of treatment, during treatment, and for one month after discontinuation of treatment with ambrisentan to prevent pregnancy [see Warnings and Precautions (5.1) ] .”