Susceptible bacterial infections (general)

Adults: 1–2 g once daily

Susceptible infections — adults: 100 mg every 12 h on day 1, then 100 mg/day

Less severe infection — >8 y and <45 kg: maintenance 2.2 mg/kg/day

Severe/life-threatening (e.g. anthrax, RMSF) — <45 kg: 2.2 mg/kg every 12 h

Serious infection — adults: 3 mg/kg/day in 3 doses (every 8 h)

Children: 2–2.5 mg/kg every 8 h

Infants and neonates (>1 week): 2.5 mg/kg every 8 h

Neonates ≤1 week: 2.5 mg/kg every 12 h