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Plague (bubonic, septicaemic, pneumonic)
Plague (bubonic, septicaemic, pneumonic) · ICD-10: A20.9
Symptoms
- • Bubonic (most common): sudden onset 2–8 days after a flea bite — fever, chills, headache, muscle pain
- • Bubonic: smooth, painful swollen lymph glands (buboes) in the groin, armpit or neck
- • Septicaemic (blood): abdominal pain, nausea, vomiting, diarrhoea, extreme weakness and shock
- • Septicaemic: bleeding into skin and organs; blackened, dying tissue of fingers, toes and nose (“Black Death”)
- • Pneumonic (most serious, the only form spread person to person): severe cough, bloody sputum, chest pain, shortness of breath
- • Seizures
Drugs and regimens
Ciprofloxacin⚠ Unverified
Plague (treatment or prophylaxis) — adult 500–750 mg every 12 h, 14 days
Ciprofloxacin⚠ Unverified
Plague — child (birth–17 y): 15 mg/kg every 8–12 h (max 500 mg), 14 days
Doxycycline⚠ Unverified
Plague — adult (general label dose)
Doxycycline⚠ Unverified
Plague — child <45 kg (severe infection): 2.2 mg/kg every 12 h
Levofloxacin⚠ Unverified
Plague — adults and children ≥50 kg: 500 mg every 24 h, 10–14 days
Levofloxacin⚠ Unverified
Plague — child 30 to <50 kg: 250 mg every 12 h, 10–14 days
Moxifloxacin⚠ Unverified
Plague (treatment or prophylaxis) — adult 400 mg once daily, 10–14 days
Streptomycin⚠ Unverified
Plague — adult: 1–2 g/day in divided doses (IM)
Streptomycin⚠ Unverified
Plague — child: 20–40 mg/kg/day in divided doses