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Narcolepsy and excessive daytime sleepiness
Narcolepsy and excessive daytime sleepiness · ICD-10: G47.419
Symptoms
- • Usually starts at 15–30 y
- • Extreme daytime sleepiness and uncontrollable sleep attacks (seconds to minutes)
- • Cataplexy: sudden loss of muscle control triggered by emotions (laughter, anger) with awareness preserved
- • Attacks during eating, talking or driving can be dangerous
Drugs and regimens
Modafinil⚠ Unverified
Narcolepsy or obstructive sleep apnoea — 200 mg once in the morning
Modafinil⚠ Unverified
Shift work disorder — 200 mg about 1 h before the shift
Pitolisant⚠ Unverified
Daytime sleepiness or cataplexy in narcolepsy — adult 17.8–35.6 mg in the morning
Sodium oxybate⚠ Unverified
Narcolepsy (cataplexy or sleepiness) — adult 4.5 g per night in two doses, up to 6–9 g