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Huntington disease chorea
Huntington disease chorea · ICD-10: G10
Symptoms
- • Quick, sudden, uncontrolled jerking of the arms, legs and face (chorea)
- • Facial grimacing; slow uncontrolled movements
- • Unsteady, wide-based gait; falls
- • Irritability, moodiness, restlessness, hallucinations or psychosis
- • Progressive dementia: confusion, loss of memory and judgement
- • Difficulty swallowing and speaking
Drugs and regimens
Deutetrabenazine⚠ Unverified
Huntington chorea — start 6 mg twice daily, +6 mg/day weekly up to 48 mg
Tetrabenazine⚠ Unverified
Huntington chorea — week 1: 12.5 mg AM; week 2: 12.5 mg twice; then +12.5 mg weekly (up to 50 mg)
Valbenazine⚠ Unverified
Huntington chorea — 40 mg once daily, +20 mg every 2 weeks to 80 mg