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Chronic myeloid leukaemia (CML) and GIST

Chronic myeloid leukaemia (CML) and GIST · ICD-10: C92.10, C49.A0

Symptoms

  • • Chronic phase: often no symptoms, found on blood tests
  • • Accelerated phase: fever without infection, bone pain, enlarged spleen
  • • Blast crisis: bruising, bleeding, infection, night sweats, fatigue, weakness
  • • Pressure under the left ribs from a large spleen; pinpoint red skin spots (petechiae)

MedlinePlus · Symptoms

Drugs and regimens

Imatinib⚠ Unverified

CML chronic phase — adult 400 mg once daily

Imatinib⚠ Unverified

CML accelerated phase or blast crisis — adult 600 mg once daily

Imatinib⚠ Unverified

Pediatric CML (≥1 y) — 340 mg/m²/day (max 600 mg)

Imatinib⚠ Unverified

Metastatic or adjuvant GIST — adult 400 mg once daily

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