Chronic myeloid leukaemia (CML)

CML (palliative) — remission induction: 4–8 mg orally daily (about 60 mcg/kg or 1.8 mg/m²)

Chronic-phase CML, adults — 100 mg once daily

Accelerated or blast-phase CML, or Ph+ ALL, adults — 140 mg once daily

Chronic-phase CML or Ph+ ALL, children — once daily by weight: 10–<20 kg: 40 mg; 20–<30: 60; 30–<45: 70; ≥45: 100 mg

Newly diagnosed Ph+ chronic-phase CML, adults — 300 mg twice daily (fasting)

Resistant or intolerant chronic- or accelerated-phase CML — 400 mg twice daily