[{"data":1,"prerenderedAt":166},["ShallowReactive",2],{"drug-zoster-vaccine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":36,"contraindications":75,"warnings":85,"renal":86,"monitoring":87,"interactions":88,"review":89,"examples":92,"atc":102,"iran":104,"usApproval":111,"links":117,"populations":132},"zoster-vaccine",1,{"fa":7,"en":8},"واکسن زونا (نوترکیب)","Recombinant zoster vaccine","anti-infectives",{"fa":11,"en":12},"واکسن نوترکیب با ادجوانت","Recombinant adjuvanted vaccine",[14],{"name":15,"market":16},"Shingrix","US",[18,19,20,21],"shingrix","شینگریکس","واکسن زونا","zoster",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"syr-05","injection","im","0.5 mL dose",{"amount":29,"unit":30,"perVolumeMl":29},0.5,"mL",[16],[33],{"source":34,"section":35},"fda-shingrix","3",[37,55],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":30,"dose":48,"refs":49,"durationDays":54},"std","herpes-zoster",{"fa":41,"en":42},"پیشگیری از زونا — ۵۰ سال به بالا: ۲ دوز ۰٫۵ mL با فاصله ۲ تا ۶ ماه","Shingles prevention — ≥50 y: 2 × 0.5 mL, 2–6 months apart",{"minAge":44},{"value":45,"unit":46},50,"year","fixed",{"perDose":29,"dosesPerDay":5},[50,52],{"source":34,"section":51},"2.4",{"source":34,"section":53},"1",{"min":5,"max":5},{"id":56,"disease":39,"label":57,"population":60,"type":47,"unit":30,"dose":63,"refs":64,"durationDays":67,"notes":68},"immuno",{"fa":58,"en":59},"نقص یا سرکوب ایمنی — ۱۸ سال به بالا: ۲ دوز با فاصله ۱ تا ۲ ماه","Immunodeficient or immunosuppressed — ≥18 y: 2 doses 1–2 months apart",{"minAge":61},{"value":62,"unit":46},18,{"perDose":29,"dosesPerDay":5},[65,66],{"source":34,"section":51},{"source":34,"section":53},{"min":5,"max":5},[69],{"text":70,"refs":73},{"fa":71,"en":72},"برای پیشگیری از آبله‌مرغان اولیه نیست.","Not for prevention of primary varicella (chickenpox).",[74],{"source":34,"section":53},[76],{"id":77,"severity":78,"text":79,"refs":82},"allergy","block",{"fa":80,"en":81},"واکنش آلرژیک شدید (آنافیلاکسی) به اجزای واکسن یا دوز قبلی.","Severe allergic reaction (anaphylaxis) to a vaccine component or a previous dose.",[83],{"source":34,"section":84},"4",[],[],[],[],{"status":90,"reviewer":91,"date":91},"unverified",null,[93,98],{"regimen":38,"formulation":24,"input":94,"expect":97},{"ageYears":95,"weightKg":96},60,70,{"perDose":29,"mlPerDose":29},{"regimen":56,"formulation":24,"input":99,"expect":101},{"ageYears":100,"weightKg":96},40,{"perDose":29,"mlPerDose":29},[103],"J07BK03",{"status":105,"refs":106},"not-found",[107],{"source":108,"section":109,"url":110},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Recombinant%20zoster%20vaccine",{"kind":112,"refs":113,"id":116},"BLA",[114],{"source":34,"section":115},"SPL approval \u002F marketing category","BLA125614",[118,121,125,129],{"kind":119,"url":120,"label":116},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=125614",{"kind":122,"url":123,"label":124},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=0280849d-5c78-4a9d-8941-4eab429f6bd8","FDA Shingrix",{"kind":126,"url":127,"label":128},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa618023.html","Zoster Vaccine, Recombinant",{"kind":130,"url":131,"label":103},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J07BK03",{"pregnancy":133,"lactation":142,"pediatric":150,"geriatric":158},{"level":134,"text":135,"quote":138,"refs":139},"caution",{"fa":136,"en":137},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary All pregnancies have a risk of birth defect, loss, or other adverse outcomes.",[140],{"source":34,"section":141},"8.1",{"level":134,"text":143,"quote":146,"refs":147},{"fa":144,"en":145},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Data are not available to assess the effects of SHINGRIX on the breastfed infant or on milk production\u002Fexcretion.",[148],{"source":34,"section":149},"8.2",{"level":134,"text":151,"quote":154,"refs":155},{"fa":152,"en":153},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness in individuals younger than 18 years have not been established.",[156],{"source":34,"section":157},"8.4",{"level":134,"text":159,"quote":162,"refs":163},{"fa":160,"en":161},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Adults Aged 60 Years and Older Of the total number of subjects who received at least 1 dose of SHINGRIX in Studies 1 and 2 (n = 14,645), 2,243 (15%) were aged 60 through 69 years, 6,837 (47%) were aged 70 through 79 years, and 1,921 (13%) were aged 80 years and older.",[164],{"source":34,"section":165},"8.5",1792156193750]