[{"data":1,"prerenderedAt":166},["ShallowReactive",2],{"drug-zoledronic-acid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":37,"contraindications":58,"warnings":68,"renal":69,"monitoring":70,"interactions":71,"review":72,"examples":75,"atc":76,"iran":78,"usApproval":98,"links":104,"populations":122},"zoledronic-acid",1,{"fa":7,"en":8},"زولدرونیک اسید (سالانه)","Zoledronic acid (yearly)","musculoskeletal",{"fa":11,"en":12},"بیس‌فسفونات وریدی","IV bisphosphonate",[14],{"name":15,"market":16},"Reclast","US",[18,19,20,21],"reclast","aclasta","آکلاستا","زولدرونیک اسید",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"bag-5","injection","iv","5 mg\u002F100 mL ready-to-infuse solution",{"amount":29,"unit":30,"perVolumeMl":31},5,"mg",100,[16],[34],{"source":35,"section":36},"fda-reclast","3",[38],{"id":39,"disease":40,"label":41,"population":44,"type":48,"unit":30,"dose":49,"refs":53},"pmo","osteoporosis",{"fa":42,"en":43},"پوکی استخوان یائسگی — ۵ mg وریدی سالی یک بار","Postmenopausal osteoporosis — 5 mg IV once a year",{"minAge":45},{"value":46,"unit":47},18,"year","notCalculated",{"reason":50},{"fa":51,"en":52},"درمان: ۵ mg انفوزیون وریدی سالی یک بار در دست‌کم ۱۵ دقیقه. پیشگیری: ۵ mg هر ۲ سال. پیش از تزریق آب کافی؛ کراتینین بررسی شود.","Treatment: 5 mg IV infusion once a year over at least 15 min. Prevention: 5 mg every 2 years. Hydrate before; check creatinine.",[54,56],{"source":35,"section":55},"2.2",{"source":35,"section":57},"2.3",[59],{"id":60,"severity":61,"text":62,"refs":65},"ci","block",{"fa":63,"en":64},"هیپوکلسمی؛ CrCl زیر ۳۵ یا آسیب حاد کلیه؛ حساسیت.","Hypocalcaemia; CrCl \u003C35 or acute renal impairment; hypersensitivity.",[66],{"source":35,"section":67},"4",[],[],[],[],{"status":73,"reviewer":74,"date":74},"unverified",null,[],[77],"M05BA08",{"status":79,"forms":80,"refs":93},"registered",[81,85,89],{"code":82,"en":83,"fa":84},"05883","ZOLEDRONIC ACID 4MG VIAL","ویال زولدرونیک اسید ۴ میلی‌گرم",{"code":86,"en":87,"fa":88},"17397","ZOLEDRONIC ACID 5MG\u002F100ML INJ","فرآورده تزریقی زولدرونیک اسید ۵ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":90,"en":91,"fa":92},"12359","ZOLEDRONIC ACID MONOHYDRATE 4MG\u002F5ML INJ","فرآورده تزریقی زولدرونیک اسید مونوهیدرات ۴ میلی‌گرم \u002F ۵ میلی‌لیتر",[94],{"source":95,"section":96,"url":97},"darooyab-generic","G-1448\u002FZoledronic-Acid","https:\u002F\u002Fwww.darooyab.ir\u002FG-1448\u002FZoledronic-Acid",{"kind":99,"refs":100,"id":103},"NDA",[101],{"source":35,"section":102},"SPL approval \u002F marketing category","NDA021817",[105,108,112,116,119],{"kind":106,"url":107,"label":103},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021817",{"kind":109,"url":110,"label":111},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=5a9b3737-9ce6-4a89-b76e-6aab79eba9cf","FDA Reclast",{"kind":113,"url":114,"label":115},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605023.html","Zoledronic Acid Injection",{"kind":117,"url":118,"label":77},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M05BA08",{"kind":120,"url":97,"label":121},"darooyab","Zoledronic-Acid",{"pregnancy":123,"lactation":132,"pediatric":141,"geriatric":150,"reproductive":158},{"level":124,"text":125,"quote":128,"refs":129},"avoid",{"fa":126,"en":127},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Discontinue Reclast when pregnancy is recognized.",[130],{"source":35,"section":131},"8.1",{"level":133,"text":134,"quote":137,"refs":138},"caution",{"fa":135,"en":136},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of zoledronic acid in human milk, the effects on the breast-fed infant, or the effects on milk production.",[139],{"source":35,"section":140},"8.2",{"level":142,"text":143,"quote":146,"refs":147},"not-established",{"fa":144,"en":145},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Reclast is not indicated for use in children.",[148],{"source":35,"section":149},"8.4",{"level":133,"text":151,"quote":154,"refs":155},{"fa":152,"en":153},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","However, because decreased renal function occurs more commonly in the elderly, special care should be taken to monitor renal function.",[156],{"source":35,"section":157},"8.5",{"level":133,"text":159,"quote":162,"refs":163},{"fa":160,"en":161},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility There are no data available in humans.",[164],{"source":35,"section":165},"8.3",1792111471956]