[{"data":1,"prerenderedAt":338},["ShallowReactive",2],{"drug-zidovudine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":12,"synonyms":16,"formulations":21,"regimens":45,"contraindications":186,"warnings":196,"renal":204,"monitoring":205,"interactions":206,"review":207,"examples":210,"atc":240,"iran":242,"links":278,"populations":299,"usApproval":333},"zidovudine",1,{"fa":7,"en":8},"زیدوودین (AZT)","Zidovudine (AZT)","anti-infectives",{"fa":11,"en":11},"NRTI",[13],{"name":14,"market":15},"Retrovir","US",[17,18,19,20],"retrovir","AZT","زیدوودین","رتروویر",[22,36],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"cap-100","capsule","oral","100 mg capsule",{"amount":28,"unit":29,"perUnit":24,"scored":30},100,"mg",false,[15],[33],{"source":34,"section":35},"fda-zidovudine","3",{"id":37,"form":38,"route":25,"label":39,"concentration":40,"markets":42,"refs":43},"syr-10","solution","10 mg\u002FmL oral solution",{"amount":41,"unit":29,"perVolumeMl":5},10,[15],[44],{"source":34,"section":35},[46,72,102,127,145,164],{"id":47,"disease":48,"label":49,"population":52,"type":56,"unit":29,"dose":57,"refs":60,"notes":63},"adult","hiv",{"fa":50,"en":51},"HIV-1 — بزرگسال: ۳۰۰ mg دو بار در روز","HIV-1 — adult: 300 mg twice daily",{"minAge":53},{"value":54,"unit":55},18,"year","fixed",{"perDose":58,"dosesPerDay":59},300,2,[61],{"source":34,"section":62},"2.1",[64],{"text":65,"refs":68},{"fa":66,"en":67},"همیشه همراه سایر داروهای ضدرتروویروس؛ دوز کودک از دوز بزرگسال بیشتر نشود.","Always with other antiretrovirals; the pediatric dose must not exceed the adult dose.",[69,70],{"source":34,"section":62},{"source":34,"section":71},"2.2",{"id":73,"disease":48,"label":74,"population":77,"type":83,"unit":29,"dose":84,"refs":86,"allowedFormulations":89,"notes":90},"child-4",{"fa":75,"en":76},"کودک ۴ تا \u003C۹ kg — ۱۲ mg\u002Fkg دو بار در روز","Child 4 to \u003C9 kg — 12 mg\u002Fkg twice daily",{"minAge":78,"maxAge":81,"minWeightKg":79,"maxWeightKg":82},{"value":79,"unit":80},4,"week",{"value":54,"unit":55},8.99,"weightBased",{"perKgPerDay":85,"dividedDoses":59},24,[87],{"source":34,"section":88},"2.2, Table 1",[37],[91,96],{"text":92,"refs":93},{"fa":66,"en":67},[94,95],{"source":34,"section":62},{"source":34,"section":71},{"text":97,"refs":100},{"fa":98,"en":99},"یا ۸ mg\u002Fkg سه بار در روز. جایگزین: ۴۸۰ mg\u002Fm²\u002Fروز.","Or 8 mg\u002Fkg three times daily. Alternative: 480 mg\u002Fm²\u002Fday.",[101],{"source":34,"section":71},{"id":103,"disease":48,"label":104,"population":107,"type":83,"unit":29,"dose":112,"refs":113,"notes":115},"child-9",{"fa":105,"en":106},"کودک ۹ تا \u003C۳۰ kg — ۹ mg\u002Fkg دو بار در روز","Child 9 to \u003C30 kg — 9 mg\u002Fkg twice daily",{"minAge":108,"maxAge":109,"minWeightKg":110,"maxWeightKg":111},{"value":79,"unit":80},{"value":54,"unit":55},9,29.99,{"perKgPerDay":54,"dividedDoses":59},[114],{"source":34,"section":88},[116,121],{"text":117,"refs":118},{"fa":66,"en":67},[119,120],{"source":34,"section":62},{"source":34,"section":71},{"text":122,"refs":125},{"fa":123,"en":124},"یا ۶ mg\u002Fkg سه بار در روز.","Or 6 mg\u002Fkg three times daily.",[126],{"source":34,"section":71},{"id":128,"disease":48,"label":129,"population":132,"type":56,"unit":29,"dose":136,"refs":137,"notes":139},"child-30",{"fa":130,"en":131},"کودک ۳۰ kg به بالا — ۳۰۰ mg دو بار در روز","Child ≥30 kg — 300 mg twice daily",{"minAge":133,"maxAge":134,"minWeightKg":135},{"value":79,"unit":80},{"value":54,"unit":55},30,{"perDose":58,"dosesPerDay":59},[138],{"source":34,"section":88},[140],{"text":141,"refs":142},{"fa":66,"en":67},[143,144],{"source":34,"section":62},{"source":34,"section":71},{"id":146,"disease":48,"label":147,"population":150,"type":56,"unit":29,"dose":152,"refs":154,"notes":157},"pmtct",{"fa":148,"en":149},"پیشگیری از انتقال مادر به جنین — مادر (بارداری بالای ۱۴ هفته): ۱۰۰ mg پنج بار در روز تا شروع زایمان","Prevention of maternal-fetal transmission — mother (>14 weeks): 100 mg five times daily until labour",{"minAge":151},{"value":54,"unit":55},{"perDose":28,"dosesPerDay":153},5,[155],{"source":34,"section":156},"2.3",[158],{"text":159,"refs":162},{"fa":160,"en":161},"حین زایمان: وریدی ۲ mg\u002Fkg در ۱ ساعت، سپس ۱ mg\u002Fkg\u002Fساعت تا بستن بند ناف.","During labour: IV 2 mg\u002Fkg over 1 h, then 1 mg\u002Fkg\u002Fh until the cord is clamped.",[163],{"source":34,"section":156},{"id":165,"disease":48,"label":166,"population":169,"type":83,"unit":29,"dose":172,"refs":173,"durationDays":176,"allowedFormulations":178,"notes":179},"neonate",{"fa":167,"en":168},"نوزاد (پیشگیری) — ۲ mg\u002Fkg خوراکی هر ۶ ساعت از ۱۲ ساعت اول تا ۶ هفتگی","Neonate (prophylaxis) — 2 mg\u002Fkg orally every 6 h from within 12 h of birth to 6 weeks",{"maxAge":170},{"value":171,"unit":80},6,{"perKgPerDose":59,"intervalHours":171},[174],{"source":34,"section":175},"2.3, Table 2",{"min":177,"max":177},42,[37],[180],{"text":181,"refs":184},{"fa":182,"en":183},"اگر خوراکی ممکن نیست: وریدی ۱٫۵ mg\u002Fkg در ۳۰ دقیقه هر ۶ ساعت. سرنگ با درجه ۰٫۱ mL.","If oral dosing is not possible: IV 1.5 mg\u002Fkg over 30 min every 6 h. Use a syringe with 0.1 mL graduations.",[185],{"source":34,"section":156},[187],{"id":188,"severity":189,"text":190,"refs":193},"hyper","block",{"fa":191,"en":192},"واکنش حساسیتی تهدیدکننده حیات (آنافیلاکسی، SJS) به زیدوودین.","Life-threatening hypersensitivity (anaphylaxis, Stevens-Johnson) to zidovudine.",[194],{"source":34,"section":195},"4",[197],{"text":198,"refs":201},{"fa":199,"en":200},"هشدار جعبه‌ای: سمیت خونی (نوتروپنی، کم‌خونی شدید)، میوپاتی، اسیدوز لاکتیک و کبد چرب.","Boxed warning: haematological toxicity (neutropenia, severe anaemia), myopathy, lactic acidosis and hepatomegaly with steatosis.",[202],{"source":34,"section":203},"Boxed Warning",[],[],[],{"status":208,"reviewer":209,"date":209},"unverified",null,[211,217,222,227,231,235],{"regimen":47,"formulation":23,"input":212,"expect":215},{"ageYears":213,"weightKg":214},35,70,{"perDose":58,"tabletsPerDoseRounded":216},3,{"regimen":73,"formulation":37,"input":218,"expect":219},{"ageMonths":79,"weightKg":171},{"perDose":220,"mlPerDose":221},72,7.2,{"regimen":103,"formulation":37,"input":223,"expect":225},{"ageYears":171,"weightKg":224},20,{"perDose":226,"mlPerDose":54},180,{"regimen":165,"formulation":37,"input":228,"expect":229},{"ageDays":59,"weightKg":216},{"perDose":171,"mlPerDose":230},0.6,{"regimen":128,"formulation":23,"input":232,"expect":234},{"ageYears":233,"weightKg":213},12,{"perDose":58,"tabletsPerDoseRounded":216},{"regimen":146,"formulation":23,"input":236,"expect":239},{"ageYears":237,"weightKg":238},28,65,{"perDose":28,"dosesPerDay":153},[241],"J05AF01",{"status":243,"forms":244,"refs":273},"registered",[245,249,253,257,261,265,269],{"code":246,"en":247,"fa":248},"01314","ZIDOVUDINE 100MG CAP","کپسول زیدوودین ۱۰۰ میلی‌گرم",{"code":250,"en":251,"fa":252},"01711","ZIDOVUDINE 250MG CAP","کپسول زیدوودین ۲۵۰ میلی‌گرم",{"code":254,"en":255,"fa":256},"15727","ZIDOVUDINE 250MG TAB","قرص زیدوودین ۲۵۰ میلی‌گرم",{"code":258,"en":259,"fa":260},"05078","ZIDOVUDINE 300MG CAP","کپسول زیدوودین ۳۰۰ میلی‌گرم",{"code":262,"en":263,"fa":264},"01775","ZIDOVUDINE 300MG TAB","قرص زیدوودین ۳۰۰ میلی‌گرم",{"code":266,"en":267,"fa":268},"01712","ZIDOVUDINE 50MG\u002F5ML SYRUP","شربت زیدوودین ۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":270,"en":271,"fa":272},"51747","ZIDOVUDINE INJECTION, SOLUTION, CONCENTRATE PARENTERAL 10 mg\u002F1mL","کنسانتره محلول تزریقی زیدوودین ۱۰ میلی‌گرم \u002F ۱ میلی‌لیتر",[274],{"source":275,"section":276,"url":277},"darooyab-generic","G-1216\u002FZidovudine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1216\u002FZidovudine",[279,283,287,291,294,297],{"kind":280,"url":281,"label":282},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=019655","NDA019655",{"kind":284,"url":285,"label":286},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=6df09f15-b102-431c-adde-d7aeef6f5d84","FDA Retrovir",{"kind":288,"url":289,"label":290},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa687007.html","Zidovudine",{"kind":288,"url":292,"label":293},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601168.html","Zidovudine Injection",{"kind":295,"url":296,"label":241},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J05AF01",{"kind":298,"url":277,"label":290},"darooyab",{"pregnancy":300,"lactation":309,"pediatric":317,"geriatric":325},{"level":301,"text":302,"quote":305,"refs":306},"caution",{"fa":303,"en":304},"برچسب: داده‌های رجیستری بارداری افزایش نقص مادرزادی نسبت به جمعیت عمومی نشان نمی‌دهد.","Label: pregnancy registry data show no increase in birth defects over the background rate.","Available data from the APR show no difference in the overall risk of birth defects for zidovudine compared with the background rate for birth defects of 2.7% in the Metropolitan Atlanta Congenital Defects Program (MACDP) reference population.",[307],{"source":34,"section":308},"8.1",{"level":301,"text":310,"quote":313,"refs":314},{"fa":311,"en":312},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary The Centers for Disease Control and Prevention recommends that HIV‑1‑infected mothers in the United States not breastfeed their infants to avoid risking postnatal transmission of HIV‑1 infection.",[315],{"source":34,"section":316},"8.2",{"level":301,"text":318,"quote":321,"refs":322},{"fa":319,"en":320},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","RETROVIR has been studied in HIV-1-infected pediatric subjects aged at least 6 weeks who had HIV-1-related symptoms or who were asymptomatic with abnormal laboratory values indicating significant HIV-1-related immunosuppression.",[323],{"source":34,"section":324},"8.4",{"level":301,"text":326,"quote":329,"refs":330},{"fa":327,"en":328},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[331],{"source":34,"section":332},"8.5",{"kind":334,"refs":335,"id":282},"NDA",[336],{"source":34,"section":337},"SPL approval \u002F marketing category",1792115199675]