[{"data":1,"prerenderedAt":186},["ShallowReactive",2],{"drug-zafirlukast":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":81,"warnings":91,"renal":99,"monitoring":100,"interactions":101,"review":102,"examples":105,"atc":116,"iran":118,"usApproval":130,"links":136,"populations":152},"zafirlukast",1,{"fa":7,"en":8},"زافیرلوکاست","Zafirlukast","respiratory",{"fa":11,"en":12},"آنتاگونیست گیرنده لکوترین","Leukotriene receptor antagonist",[14],{"name":15,"market":16},"Accolate","US",[18,19,7],"accolate","آکولیت",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-20","tablet","oral","20 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},20,"mg",false,[16],[32],{"source":33,"section":34},"fda-zafirlukast","How Supplied",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-10","10 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},10,[16],[42],{"source":33,"section":34},[44,68],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":57,"allowedFormulations":60,"notes":61},"adult","asthma",{"fa":48,"en":49},"پیشگیری و درمان مزمن آسم (۱۲ سال به بالا) — ۲۰ mg دو بار در روز","Asthma prophylaxis and chronic treatment (≥12 y) — 20 mg twice daily",{"minAge":51},{"value":52,"unit":53},12,"year","fixed",{"perDose":27,"dosesPerDay":56},2,[58],{"source":33,"section":59},"Dosage and Administration",[22],[62],{"text":63,"refs":66},{"fa":64,"en":65},"دست‌کم ۱ ساعت قبل یا ۲ ساعت بعد از غذا. برای برونکواسپاسم حاد نیست.","At least 1 h before or 2 h after meals. Not for acute bronchospasm.",[67],{"source":33,"section":59},{"id":69,"disease":46,"label":70,"population":73,"type":54,"unit":28,"dose":77,"refs":78,"allowedFormulations":80},"child",{"fa":71,"en":72},"کودک ۵ تا ۱۱ سال — ۱۰ mg دو بار در روز","Children 5–11 y — 10 mg twice daily",{"minAge":74,"maxAge":76},{"value":75,"unit":53},5,{"value":52,"unit":53},{"perDose":39,"dosesPerDay":56},[79],{"source":33,"section":59},[36],[82],{"id":83,"severity":84,"text":85,"refs":88},"ci","block",{"fa":86,"en":87},"حساسیت به زافیرلوکاست؛ نارسایی کبد از جمله سیروز.","Hypersensitivity to zafirlukast; hepatic impairment including cirrhosis.",[89],{"source":33,"section":90},"Contraindications",[92],{"text":93,"refs":96},{"fa":94,"en":95},"سمیت کبدی و نارسایی کبد تهدیدکننده حیات — با علائم کبدی قطع و آزمایش.","Hepatotoxicity including life-threatening hepatic failure — stop and test if hepatic symptoms.",[97],{"source":33,"section":98},"Warnings",[],[],[],{"status":103,"reviewer":104,"date":104},"unverified",null,[106,111],{"regimen":45,"formulation":22,"input":107,"expect":110},{"ageYears":108,"weightKg":109},30,70,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":69,"formulation":36,"input":112,"expect":115},{"ageYears":113,"weightKg":114},8,25,{"perDose":39,"tabletsPerDoseRounded":5},[117],"R03DC01",{"status":119,"forms":120,"refs":125},"registered",[121],{"code":122,"en":123,"fa":124},"01894","ZAFIRLUKAST 20MG TAB","قرص زافیرلوکاست ۲۰ میلی‌گرم",[126],{"source":127,"section":128,"url":129},"darooyab-generic","G-1501\u002FZafirlukast","https:\u002F\u002Fwww.darooyab.ir\u002FG-1501\u002FZafirlukast",{"kind":131,"refs":132,"id":135},"NDA authorized generic",[133],{"source":33,"section":134},"SPL approval \u002F marketing category","NDA020547",[137,140,144,147,150],{"kind":138,"url":139,"label":135},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020547",{"kind":141,"url":142,"label":143},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=baba507f-6557-4551-815c-9ab6606e4ee1","FDA Zafirlukast",{"kind":145,"url":146,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa697007.html",{"kind":148,"url":149,"label":117},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R03DC01",{"kind":151,"url":129,"label":8},"darooyab",{"pregnancy":153,"lactation":162,"pediatric":170,"geriatric":178},{"level":154,"text":155,"quote":158,"refs":159},"caution",{"fa":156,"en":157},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Category B: No teratogenicity was observed at oral doses up to 1600 mg\u002Fkg\u002Fday in mice (approximately 160 times the maximum recommended daily oral dose in adults on a mg\u002Fm 2 basis), up to 2000 mg\u002Fkg\u002Fday in rats (approximately 410 times the maximum recommended daily oral dose in adults on a mg\u002Fm 2 basis) and up to 2000 …",[160],{"source":33,"section":161},"Precautions\u002FWarnings – Pregnancy",{"level":154,"text":163,"quote":166,"refs":167},{"fa":164,"en":165},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Zafirlukast is excreted in breast milk.",[168],{"source":33,"section":169},"Precautions\u002FWarnings – Nursing Mothers",{"level":154,"text":171,"quote":174,"refs":175},{"fa":172,"en":173},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of zafirlukast for pediatric patients less than 5 years of age has not been established.",[176],{"source":33,"section":177},"Precautions\u002FWarnings – Pediatric Use",{"level":154,"text":179,"quote":182,"refs":183},{"fa":180,"en":181},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Based on cross-study comparison, the clearance of zafirlukast is reduced in patients 65 years of age and older such that C max and AUC are approximately 2- to 3-fold greater than those of younger patients (see",[184],{"source":33,"section":185},"Precautions\u002FWarnings – Geriatric Use",1792191573480]