[{"data":1,"prerenderedAt":209},["ShallowReactive",2],{"drug-vonoprazan":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":106,"warnings":116,"renal":117,"monitoring":118,"interactions":119,"review":120,"examples":123,"atc":135,"iran":137,"usApproval":153,"links":159,"populations":175},"vonoprazan",1,{"fa":7,"en":8},"وونوپرازان","Vonoprazan","alimentary-metabolism",{"fa":11,"en":12},"مسدودکننده رقابتی پمپ اسید (P-CAB)","Potassium-competitive acid blocker",[14],{"name":15,"market":16},"Voquezna","US",[18,19,7],"voquezna","takecab",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-10","tablet","oral","10 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},10,"mg",false,[16],[32],{"source":33,"section":34},"fda-voquezna","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-20","20 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},20,[16],[42],{"source":33,"section":34},[44,70,83],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":56,"durationDays":59,"notes":61},"ee","erosive-esophagitis",{"fa":48,"en":49},"ازوفاژیت اروزیو — ۲۰ mg یک بار در روز، ۸ هفته","Erosive oesophagitis healing — 20 mg once daily, 8 weeks",{"minAge":51},{"value":52,"unit":53},18,"year","fixed",{"perDose":39,"dosesPerDay":5},[57],{"source":33,"section":58},"2.1",{"min":60,"max":60},56,[62],{"text":63,"refs":66},{"fa":64,"en":65},"نگهدارنده: ۱۰ mg یک بار در روز تا ۶ ماه. GFR زیر ۳۰: ۱۰ mg.","Maintenance: 10 mg once daily up to 6 months. GFR \u003C30: 10 mg.",[67,68],{"source":33,"section":58},{"source":33,"section":69},"2.2, Table 1",{"id":71,"disease":72,"label":73,"population":76,"type":54,"unit":28,"dose":78,"refs":79,"durationDays":81},"nerd","gerd",{"fa":74,"en":75},"سوزش سر دل در ریفلاکس غیراروزیو — ۱۰ mg یک بار در روز، ۴ هفته","Heartburn in non-erosive GERD — 10 mg once daily, 4 weeks",{"minAge":77},{"value":52,"unit":53},{"perDose":27,"dosesPerDay":5},[80],{"source":33,"section":58},{"min":82,"max":82},28,{"id":84,"disease":85,"label":86,"population":89,"type":54,"unit":28,"dose":91,"refs":93,"durationDays":95,"notes":97},"hp","h-pylori",{"fa":87,"en":88},"هلیکوباکتر پیلوری — ۲۰ mg دو بار در روز، ۱۴ روز (همراه آموکسی‌سیلین ± کلاریترومایسین)","H. pylori — 20 mg twice daily, 14 days (with amoxicillin ± clarithromycin)",{"minAge":90},{"value":52,"unit":53},{"perDose":39,"dosesPerDay":92},2,[94],{"source":33,"section":58},{"min":96,"max":96},14,[98],{"text":99,"refs":102},{"fa":100,"en":101},"سه‌گانه: + آموکسی‌سیلین ۱۰۰۰ mg و کلاریترومایسین ۵۰۰ mg هر کدام دو بار در روز. دوگانه: + آموکسی‌سیلین ۱۰۰۰ mg سه بار در روز. GFR زیر ۳۰ توصیه نمی‌شود.","Triple: + amoxicillin 1,000 mg and clarithromycin 500 mg each twice daily. Dual: + amoxicillin 1,000 mg three times daily. Not recommended with GFR \u003C30.",[103,104],{"source":33,"section":58},{"source":33,"section":105},"2.2, Table 2",[107],{"id":108,"severity":109,"text":110,"refs":113},"ci","block",{"fa":111,"en":112},"حساسیت به وونوپرازان؛ داروهای حاوی ریلپیویرین.","Hypersensitivity to vonoprazan; rilpivirine-containing products.",[114],{"source":33,"section":115},"4",[],[],[],[],{"status":121,"reviewer":122,"date":122},"unverified",null,[124,129,132],{"regimen":45,"formulation":36,"input":125,"expect":128},{"ageYears":126,"weightKg":127},45,75,{"perDose":39,"tabletsPerDoseRounded":5},{"regimen":71,"formulation":22,"input":130,"expect":131},{"ageYears":126,"weightKg":127},{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":84,"formulation":36,"input":133,"expect":134},{"ageYears":126,"weightKg":127},{"perDose":39,"tabletsPerDoseRounded":5},[136],"A02BC08",{"status":138,"forms":139,"refs":148},"registered",[140,144],{"code":141,"en":142,"fa":143},"53384","VONOPRAZAN 10MG TABLET","قرص وونوپرازان ۱۰ میلی‌گرم",{"code":145,"en":146,"fa":147},"53385","VONOPRAZAN 20MG TABLET","قرص وونوپرازان ۲۰ میلی‌گرم",[149],{"source":150,"section":151,"url":152},"darooyab-generic","G-5544\u002FVonoprazan","https:\u002F\u002Fwww.darooyab.ir\u002FG-5544\u002FVonoprazan",{"kind":154,"refs":155,"id":158},"NDA",[156],{"source":33,"section":157},"SPL approval \u002F marketing category","NDA215151",[160,163,167,170,173],{"kind":161,"url":162,"label":158},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=215151",{"kind":164,"url":165,"label":166},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=0cc52ac5-77ec-4d66-a770-762a1a960914","FDA Voquezna",{"kind":168,"url":169,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa624006.html",{"kind":171,"url":172,"label":136},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A02BC08",{"kind":174,"url":152,"label":8},"darooyab",{"pregnancy":176,"lactation":185,"pediatric":193,"geriatric":201},{"level":177,"text":178,"quote":181,"refs":182},"caution",{"fa":179,"en":180},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate and well-controlled studies of vonoprazan in pregnant women.",[183],{"source":33,"section":184},"8.1",{"level":177,"text":186,"quote":189,"refs":190},{"fa":187,"en":188},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Data from a clinical lactation study indicate that vonoprazan is present in human breast milk in amounts less than 0.03% of the administered maternal dose.",[191],{"source":33,"section":192},"8.2",{"level":177,"text":194,"quote":197,"refs":198},{"fa":195,"en":196},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of VOQUEZNA have not been established in pediatric patients.",[199],{"source":33,"section":200},"8.4",{"level":177,"text":202,"quote":205,"refs":206},{"fa":203,"en":204},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","There were 200 patients aged 65 years and older in the clinical trial for healing and maintenance of healed erosive esophagitis [see Clinical Studies (14.1) ] .",[207],{"source":33,"section":208},"8.5",1792111471559]