[{"data":1,"prerenderedAt":195},["ShallowReactive",2],{"drug-vinorelbine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":66,"warnings":67,"renal":82,"monitoring":83,"interactions":84,"review":85,"examples":88,"atc":97,"iran":99,"usApproval":127,"links":133,"populations":150},"vinorelbine",1,{"fa":7,"en":8},"وینورلبین","Vinorelbine","antineoplastic-immunomodulating",{"fa":11,"en":12},"آلکالوئید وینکا","Vinca alkaloid",[14],{"name":15,"market":16},"Navelbine","US",[18,19,7],"navelbine","ناولبین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"inj-10","injection","iv","10 mg\u002FmL (10 mg\u002F1 mL, 50 mg\u002F5 mL)",{"amount":27,"unit":28,"perVolumeMl":5},10,"mg",[16],[31],{"source":32,"section":33},"fda-vinorelbine","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":48,"durationDays":51,"notes":52},"nsclc","lung-cancer",{"fa":39,"en":40},"سرطان ریه غیرسلول کوچک — ۳۰ mg\u002Fm² وریدی هفته‌ای یک بار (تک‌دارویی یا با سیس‌پلاتین ۲۵ تا ۳۰)","Non-small-cell lung cancer — 30 mg\u002Fm² IV once weekly (single agent, or 25–30 with cisplatin)",{"minAge":42},{"value":43,"unit":44},18,"year","bsa",{"perM2PerDay":47,"dividedDoses":5},30,[49],{"source":32,"section":50},"2.1",{"min":5,"max":5},[53,59],{"text":54,"refs":57},{"fa":55,"en":56},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[58],{"source":32,"section":50},{"text":60,"refs":63},{"fa":61,"en":62},"با کاهش نوتروفیل یا افزایش بیلی‌روبین طبق جداول ۲.۲ کم یا قطع شود. فقط وریدی.","Reduce or withhold for low neutrophils or raised bilirubin per 2.2 tables. IV only.",[64],{"source":32,"section":65},"2.2",[],[68,75],{"text":69,"refs":72},{"fa":70,"en":71},"هشدار جعبه‌ای: سرکوب شدید مغز استخوان (عفونت، شوک سپتیک، مرگ).","Boxed warning: severe myelosuppression (infection, septic shock, death).",[73],{"source":32,"section":74},"Boxed Warning",{"text":76,"refs":79},{"fa":77,"en":78},"سمیت کبدی؛ یبوست شدید و انسداد روده؛ نشت از رگ؛ نوروپاتی؛ سمیت ریوی؛ سمیت جنینی.","Hepatotoxicity; severe constipation and bowel obstruction; extravasation; neuropathy; pulmonary toxicity; embryo-fetal toxicity.",[80],{"source":32,"section":81},"5",[],[],[],{"status":86,"reviewer":87,"date":87},"unverified",null,[89],{"regimen":36,"formulation":22,"input":90,"expect":94},{"ageYears":91,"weightKg":92,"heightCm":93},55,80,180,{"perDose":95,"mlPerDose":96},60,6,[98],"L01CA04",{"status":100,"forms":101,"refs":122},"registered",[102,106,110,114,118],{"code":103,"en":104,"fa":105},"05005","VINORELBINE 10MG\u002F1ML VIAL","ویال وینورلبین ۱۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":107,"en":108,"fa":109},"13254","VINORELBINE 20MG CAP","کپسول وینورلبین ۲۰ میلی‌گرم",{"code":111,"en":112,"fa":113},"08133","VINORELBINE 30MG CAP","کپسول وینورلبین ۳۰ میلی‌گرم",{"code":115,"en":116,"fa":117},"20043","VINORELBINE 500MG\u002F10ML VIAL","ویال وینورلبین ۵۰۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",{"code":119,"en":120,"fa":121},"05006","VINORELBINE 50MG\u002F5ML VIAL","ویال وینورلبین ۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",[123],{"source":124,"section":125,"url":126},"darooyab-generic","G-1093\u002FVinorelbine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1093\u002FVinorelbine",{"kind":128,"refs":129,"id":132},"ANDA",[130],{"source":32,"section":131},"SPL approval \u002F marketing category","ANDA091106",[134,137,141,145,148],{"kind":135,"url":136,"label":132},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=091106",{"kind":138,"url":139,"label":140},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=10a70995-e04d-4044-b1dc-c9aa27460397","FDA Vinorelbine",{"kind":142,"url":143,"label":144},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695013.html","Vinorelbine Injection",{"kind":146,"url":147,"label":98},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01CA04",{"kind":149,"url":126,"label":8},"darooyab",{"pregnancy":151,"lactation":160,"pediatric":168,"geriatric":177,"reproductive":186},{"level":152,"text":153,"quote":156,"refs":157},"avoid",{"fa":154,"en":155},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on findings from animal studies and its mechanism of action [see Clinical Pharmacology ( 12.1 )] , vinorelbine can cause fetal harm when administered to a pregnant woman.",[158],{"source":32,"section":159},"8.1",{"level":152,"text":161,"quote":164,"refs":165},{"fa":162,"en":163},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in breastfed infants from vinorelbine, advise women not to breastfeed during treatment with vinorelbine and for 9 days after the final dose.",[166],{"source":32,"section":167},"8.2",{"level":169,"text":170,"quote":173,"refs":174},"not-established",{"fa":171,"en":172},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of vinorelbine in pediatric patients have not been established.",[175],{"source":32,"section":176},"8.4",{"level":178,"text":179,"quote":182,"refs":183},"ok",{"fa":180,"en":181},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety, efficacy and pharmacokinetic parameters were observed between these patients and younger patients [see Clinical Pharmacology ( 12.3 )] .",[184],{"source":32,"section":185},"8.5",{"level":187,"text":188,"quote":191,"refs":192},"caution",{"fa":189,"en":190},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females Vinorelbine can cause fetal harm when administered to pregnant women [see Use in Specific Populations ( 8.1 )] .",[193],{"source":32,"section":194},"8.3",1792444429183]