[{"data":1,"prerenderedAt":140},["ShallowReactive",2],{"drug-valproic-acid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":38,"contraindications":88,"warnings":117,"renal":118,"monitoring":119,"interactions":120,"review":121,"examples":124},"valproic-acid",1,{"fa":7,"en":8},"والپروئیک اسید (شربت)","Valproic acid (oral solution)","neurology",{"fa":11,"en":12},"ضدتشنج","Anticonvulsant",[14],{"name":15,"market":16},"Depakene","US",[18,19,20,21,22],"depakene","دپاکین","والپروات","والپروات سدیم","شربت والپروات",[24],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"sol-250","solution","oral","250 mg\u002F5 mL oral solution",{"amount":30,"unit":31,"perVolumeMl":32},250,"mg",5,[16],[35],{"source":36,"section":37},"fda-valproicsol","3",[39,67],{"id":40,"disease":41,"label":42,"population":45,"type":49,"unit":31,"dose":50,"refs":53,"limits":56,"notes":60},"cps","epilepsy",{"fa":43,"en":44},"صرع پارشیل پیچیده — ۱۰ سال به بالا: شروع ۱۰ تا ۱۵ mg\u002Fkg\u002Fday","Complex partial seizures — ≥10 y: start 10–15 mg\u002Fkg\u002Fday",{"minAge":46},{"value":47,"unit":48},10,"year","weightBased",{"perKgPerDay":47,"perKgPerDayMax":51,"dividedDoses":52},15,2,[54],{"source":36,"section":55},"2.1",{"maxPerKgPerDay":57,"refs":58},60,[59],{"source":36,"section":55},[61],{"text":62,"refs":65},{"fa":63,"en":64},"افزایش ۵ تا ۱۰ mg\u002Fkg\u002Fهفته؛ معمولاً پاسخ زیر ۶۰ mg\u002Fkg\u002Fday؛ سطح خونی ۵۰ تا ۱۰۰ mcg\u002FmL. اگر بیش از ۲۵۰ mg\u002Fday، منقسم.","Increase by 5–10 mg\u002Fkg\u002Fweek; usual response below 60 mg\u002Fkg\u002Fday; levels 50–100 mcg\u002FmL. Divide if >250 mg\u002Fday.",[66],{"source":36,"section":55},{"id":68,"disease":41,"label":69,"population":72,"type":49,"unit":31,"dose":74,"refs":75,"limits":78,"notes":81},"absence",{"fa":70,"en":71},"صرع ابسانس — شروع ۱۵ mg\u002Fkg\u002Fday","Absence seizures — start 15 mg\u002Fkg\u002Fday",{"minAge":73},{"value":52,"unit":48},{"perKgPerDay":51,"dividedDoses":52},[76],{"source":36,"section":77},"2",{"maxPerKgPerDay":57,"refs":79},[80],{"source":36,"section":77},[82],{"text":83,"refs":86},{"fa":84,"en":85},"افزایش هفتگی ۵ تا ۱۰ mg\u002Fkg؛ بی‌خطری بالای ۶۰ mg\u002Fkg\u002Fday ثابت نشده.","Increase by 5–10 mg\u002Fkg weekly; safety above 60 mg\u002Fkg\u002Fday not established.",[87],{"source":36,"section":77},[89,100,108],{"id":90,"severity":91,"rule":92,"text":94,"refs":97},"under-2","block",{"maxAge":93},{"value":52,"unit":48},{"fa":95,"en":96},"زیر ۲ سال خطر کشنده آسیب کبدی بسیار بالاتر است.","Under 2 years: considerably higher risk of fatal hepatotoxicity.",[98],{"source":36,"section":99},"8.4",{"id":101,"severity":91,"text":102,"refs":105},"ci",{"fa":103,"en":104},"بیماری یا اختلال قابل‌توجه کبد؛ اختلال میتوکندریایی POLG؛ حساسیت؛ اختلال چرخه اوره؛ برای پیشگیری میگرن: بارداری یا عدم پیشگیری مؤثر.","Hepatic disease or significant dysfunction; POLG mitochondrial disorders; hypersensitivity; urea-cycle disorders; for migraine prophylaxis: pregnancy or no effective contraception.",[106],{"source":36,"section":107},"4",{"id":109,"severity":110,"text":111,"refs":114},"boxed","warn",{"fa":112,"en":113},"هشدار جعبه‌ای: سمیت کبدی، تراتوژنیسیته، پانکراتیت.","Boxed warning: hepatotoxicity, teratogenicity, pancreatitis.",[115],{"source":36,"section":116},"Boxed Warning",[],[],[],[],{"status":122,"reviewer":123,"date":123},"unverified",null,[125,133],{"regimen":40,"formulation":25,"input":126,"expect":129},{"ageYears":127,"weightKg":128},12,40,{"perDose":130,"mlPerDose":131,"upperPerDose":132},200,4,300,{"regimen":68,"formulation":25,"input":134,"expect":137},{"ageYears":135,"weightKg":136},6,20,{"perDose":138,"mlPerDose":139},150,3,1792078541627]