[{"data":1,"prerenderedAt":190},["ShallowReactive",2],{"drug-theophylline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":143,"warnings":153,"renal":161,"monitoring":162,"interactions":163,"review":164,"examples":167},"theophylline",1,{"fa":7,"en":8},"تئوفیلین","Theophylline","respiratory",{"fa":11,"en":12},"متیل‌گزانتین؛ برونکودیلاتور","Methylxanthine bronchodilator",[14],{"name":15,"market":16},"Elixophyllin","US",[18,19,20],"theophyllin","تئوفیلین جی","theophylline g",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"sol-80-15","solution","oral","80 mg \u002F 15 mL",{"amount":28,"unit":29,"perVolumeMl":30},80,"mg",15,[16],[33],{"source":34,"section":35},"fda-theophylline-sol","Description",[37,68,88,109,129],{"id":38,"disease":39,"label":40,"population":43,"type":49,"unit":29,"dose":50,"refs":54,"limits":57,"notes":61},"child-step1","asthma",{"fa":41,"en":42},"کودکان ۱ تا ۱۵ سال، زیر ۴۵ کیلوگرم — شروع: ۱۲ تا ۱۴ mg\u002Fkg\u002Fday","Children 1–15 y, \u003C45 kg — start: 12–14 mg\u002Fkg\u002Fday",{"minAge":44,"maxAge":46,"maxWeightKg":48},{"value":5,"unit":45},"year",{"value":47,"unit":45},16,45,"weightBased",{"perKgPerDay":51,"perKgPerDayMax":52,"dividedDoses":53},12,14,4,[55],{"source":34,"section":56},"Dosage and Administration, Table V",{"maxPerDay":58,"refs":59},300,[60],{"source":34,"section":56},[62],{"text":63,"refs":66},{"fa":64,"en":65},"در عوامل خطر کاهش کلیرانس یا وقتی پایش سطح سرمی ممکن نیست، دوز نهایی کودکان ۱ تا ۱۵ سال از ۱۶ mg\u002Fkg\u002Fday (حداکثر ۴۰۰ mg\u002Fday) بیشتر نشود. حاشیه درمانی باریک؛ پایش سطح سرمی.","With risk factors for reduced clearance or if serum levels cannot be monitored, the final dose for 1–15 years must not exceed 16 mg\u002Fkg\u002Fday (max 400 mg\u002Fday). Narrow therapeutic index; monitor serum levels.",[67],{"source":34,"section":56},{"id":69,"disease":39,"label":70,"population":73,"type":49,"unit":29,"dose":76,"refs":77,"limits":79,"notes":83},"child-step2",{"fa":71,"en":72},"کودکان زیر ۴۵ کیلوگرم — پس از ۳ روز: ۱۶ mg\u002Fkg\u002Fday","Children \u003C45 kg — after 3 days: 16 mg\u002Fkg\u002Fday",{"minAge":74,"maxAge":75,"maxWeightKg":48},{"value":5,"unit":45},{"value":47,"unit":45},{"perKgPerDay":47,"dividedDoses":53},[78],{"source":34,"section":56},{"maxPerDay":80,"refs":81},400,[82],{"source":34,"section":56},[84],{"text":85,"refs":86},{"fa":64,"en":65},[87],{"source":34,"section":56},{"id":89,"disease":39,"label":90,"population":93,"type":49,"unit":29,"dose":96,"refs":98,"limits":100,"notes":104},"child-step3",{"fa":91,"en":92},"کودکان زیر ۴۵ کیلوگرم — پس از ۳ روز دیگر: ۲۰ mg\u002Fkg\u002Fday","Children \u003C45 kg — after 3 more days: 20 mg\u002Fkg\u002Fday",{"minAge":94,"maxAge":95,"maxWeightKg":48},{"value":5,"unit":45},{"value":47,"unit":45},{"perKgPerDay":97,"dividedDoses":53},20,[99],{"source":34,"section":56},{"maxPerDay":101,"refs":102},600,[103],{"source":34,"section":56},[105],{"text":106,"refs":107},{"fa":64,"en":65},[108],{"source":34,"section":56},{"id":110,"disease":39,"label":111,"population":114,"type":115,"unit":29,"dose":116,"refs":120,"notes":122},"adult",{"fa":112,"en":113},"بیش از ۴۵ کیلوگرم و بزرگسال — شروع ۳۰۰ mg\u002Fday",">45 kg and adults — start 300 mg\u002Fday",{"minWeightKg":48},"titration",{"dividedDoses":53,"titration":117},{"start":58,"increment":118,"incrementEveryDays":119,"targetMin":80,"targetMax":101,"max":101},100,3,[121],{"source":34,"section":56},[123],{"text":124,"refs":127},{"fa":125,"en":126},"۳۰۰ ← ۴۰۰ ← ۶۰۰ mg\u002Fday هر ۳ روز در صورت تحمل، در دوزهای هر ۶ تا ۸ ساعت. با عوامل خطر یا بالای ۶۰ سال حداکثر ۴۰۰ mg\u002Fday.","300 → 400 → 600 mg\u002Fday every 3 days if tolerated, divided every 6–8 h. With risk factors or over 60 years, max 400 mg\u002Fday.",[128],{"source":34,"section":56},{"id":130,"disease":39,"label":131,"population":134,"type":136,"unit":29,"dose":137,"refs":141},"infant",{"fa":132,"en":133},"شیرخوار زیر ۱ سال","Infants under 1 year",{"maxAge":135},{"value":5,"unit":45},"notCalculated",{"reason":138},{"fa":139,"en":140},"فرمول برچسب: دوز روزانه (mg) = [(۰٫۲ × سن به هفته) + ۵] × وزن (kg)؛ زیر ۲۶ هفته در ۳ نوبت، ۲۶ هفته به بالا در ۴ نوبت. نوزاد نارس: ۱ تا ۱٫۵ mg\u002Fkg هر ۱۲ ساعت. تنظیم با سطح سرمی؛ محاسبه خودکار انجام نمی‌شود.","Label formula: total daily dose (mg) = [(0.2 × age in weeks) + 5] × kg; \u003C26 weeks in 3 doses, ≥26 weeks in 4 doses. Premature neonates: 1–1.5 mg\u002Fkg every 12 h. Titrate to serum level; not auto-calculated.",[142],{"source":34,"section":56},[144],{"id":145,"severity":146,"text":147,"refs":150},"hypersensitivity","block",{"fa":148,"en":149},"حساسیت به تئوفیلین یا اجزای فرآورده.","Hypersensitivity to theophylline or other components.",[151],{"source":34,"section":152},"Contraindications",[154],{"text":155,"refs":158},{"fa":156,"en":157},"با احتیاط شدید در زخم پپتیک فعال، اختلال تشنجی و سایر بیماری‌های همزمان.","Use with extreme caution in active peptic ulcer disease, seizure disorders and other concurrent illness.",[159],{"source":34,"section":160},"Warnings",[],[],[],{"status":165,"reviewer":166,"date":166},"unverified",null,[168,175,178,181,185],{"regimen":38,"formulation":23,"input":169,"expect":171},{"ageYears":170,"weightKg":97},6,{"perDose":172,"upperPerDose":173,"mlPerDose":174},60,70,11.25,{"regimen":69,"formulation":23,"input":176,"expect":177},{"ageYears":170,"weightKg":97},{"perDose":28,"mlPerDose":30},{"regimen":89,"formulation":23,"input":179,"expect":180},{"ageYears":170,"weightKg":97},{"perDose":118,"perDay":80},{"regimen":89,"formulation":23,"input":182,"expect":184},{"ageYears":52,"weightKg":183},40,{"perDay":101},{"regimen":110,"formulation":23,"input":186,"expect":188},{"ageYears":187,"weightKg":173},30,{"perDose":189},75,1792078540941]