[{"data":1,"prerenderedAt":166},["ShallowReactive",2],{"drug-tdap-vaccine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":36,"contraindications":73,"warnings":90,"renal":91,"monitoring":92,"interactions":93,"review":94,"examples":97,"atc":106,"iran":108,"links":115,"populations":127,"usApproval":161},"tdap-vaccine",1,{"fa":7,"en":8},"واکسن کزاز، دیفتری و سیاه‌سرفه (Tdap)","Tdap vaccine (tetanus, diphtheria, pertussis)","anti-infectives",{"fa":11,"en":12},"واکسن غیرفعال","Inactivated vaccine",[14],{"name":15,"market":16},"Boostrix","US",[18,19,20,21,22],"boostrix","adacel","Tdap","واکسن کزاز","سه گانه بزرگسال",[24],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":31,"refs":32},"syr-05","injection","im","0.5 mL prefilled syringe \u002F vial",{"amount":5,"unit":30,"perVolumeMl":5},"mL",[16],[33],{"source":34,"section":35},"fda-boostrix","3",[37,61],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":30,"dose":48,"refs":50,"durationDays":53,"notes":54},"booster","immunization",{"fa":41,"en":42},"یادآور — ۱۰ سال به بالا: ۰٫۵ mL عضلانی","Booster — ≥10 y: 0.5 mL IM",{"minAge":44},{"value":45,"unit":46},10,"year","fixed",{"perDose":49,"dosesPerDay":5},0.5,[51],{"source":34,"section":52},"2.2",{"min":5,"max":5},[55],{"text":56,"refs":59},{"fa":57,"en":58},"۵ سال یا بیشتر پس از آخرین DTaP یا Td؛ دوز اضافه ۹ سال یا بیشتر پس از Tdap قبلی. بارداری: یک دوز در سه‌ماهه سوم برای محافظت نوزاد از سیاه‌سرفه.","≥5 years after the last DTaP or Td; an additional dose ≥9 years after a previous Tdap. Pregnancy: one dose in the third trimester to protect the infant from pertussis.",[60],{"source":34,"section":52},{"id":62,"disease":63,"label":64,"population":67,"type":47,"unit":30,"dose":69,"refs":70,"durationDays":72},"wound","tetanus-prophylaxis",{"fa":65,"en":66},"زخم مستعد کزاز — ۰٫۵ mL اگر ۵ سال یا بیشتر از واکسن قبلی گذشته","Tetanus-prone wound — 0.5 mL if ≥5 years since the last tetanus vaccine",{"minAge":68},{"value":45,"unit":46},{"perDose":49,"dosesPerDay":5},[71],{"source":34,"section":52},{"min":5,"max":5},[74,83],{"id":75,"severity":76,"text":77,"refs":80},"allergy","block",{"fa":78,"en":79},"آنافیلاکسی به دوز قبلی واکسن حاوی کزاز، دیفتری یا سیاه‌سرفه یا اجزای Boostrix.","Anaphylaxis after a previous tetanus-, diphtheria- or pertussis-containing vaccine or to any Boostrix component.",[81],{"source":34,"section":82},"4",{"id":84,"severity":76,"text":85,"refs":88},"enceph",{"fa":86,"en":87},"انسفالوپاتی ظرف ۷ روز پس از واکسن حاوی سیاه‌سرفه.","Encephalopathy within 7 days of a previous pertussis-containing vaccine.",[89],{"source":34,"section":82},[],[],[],[],{"status":95,"reviewer":96,"date":96},"unverified",null,[98,103],{"regimen":38,"formulation":25,"input":99,"expect":102},{"ageYears":100,"weightKg":101},30,70,{"perDose":49,"mlPerDose":49},{"regimen":62,"formulation":25,"input":104,"expect":105},{"ageYears":100,"weightKg":101},{"perDose":49,"mlPerDose":49},[107],"J07AJ52",{"status":109,"refs":110},"not-found",[111],{"source":112,"section":113,"url":114},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Tdap%20vaccine",[116,120,124],{"kind":117,"url":118,"label":119},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=125106","BLA125106",{"kind":121,"url":122,"label":123},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=cd98bff9-4602-4268-d68d-029a14a5513b","FDA Boostrix",{"kind":125,"url":126,"label":107},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J07AJ52",{"pregnancy":128,"lactation":137,"pediatric":145,"geriatric":153},{"level":129,"text":130,"quote":133,"refs":134},"caution",{"fa":131,"en":132},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary All pregnancies have a risk of birth defect, loss, or other adverse outcomes.",[135],{"source":34,"section":136},"8.1",{"level":129,"text":138,"quote":141,"refs":142},{"fa":139,"en":140},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Data are not available to assess the effect of administration of BOOSTRIX on breastfed infants or on milk production\u002Fexcretion.",[143],{"source":34,"section":144},"8.2",{"level":129,"text":146,"quote":149,"refs":150},{"fa":147,"en":148},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","BOOSTRIX is not indicated for use in children aged younger than 10 years.",[151],{"source":34,"section":152},"8.4",{"level":129,"text":154,"quote":157,"refs":158},{"fa":155,"en":156},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In the initial‑dose clinical trials, 1,104 participants aged 65 years and older received BOOSTRIX; of these participants, 299 were aged 75 years and older.",[159],{"source":34,"section":160},"8.5",{"kind":162,"refs":163,"id":119},"BLA",[164],{"source":34,"section":165},"SPL approval \u002F marketing category",1792108438023]