[{"data":1,"prerenderedAt":270},["ShallowReactive",2],{"drug-sodium-bicarbonate":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":36,"contraindications":93,"warnings":103,"renal":104,"monitoring":105,"interactions":106,"review":107,"examples":110,"atc":125,"iran":127,"usApproval":209,"links":215,"populations":236},"sodium-bicarbonate",1,{"fa":7,"en":8},"بیکربنات سدیم (تزریقی)","Sodium bicarbonate (injection)","blood",{"fa":11,"en":12},"قلیایی‌کننده","Alkalinising agent",[14],{"name":15,"market":16},"Sodium bicarbonate","US",[18,19,20,21],"bicarbonate","بی کربنات","جوش شیرین تزریقی","NaHCO3",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"bag-015","injection","iv","12.6 mg\u002FmL (0.150 mEq\u002FmL) isotonic 1000 mL",{"amount":29,"unit":30,"perVolumeMl":5},0.15,"mEq",[16],[33],{"source":34,"section":35},"fda-bicarbonate","3",[37,71],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":30,"dose":48,"refs":50,"durationDays":53,"notes":54},"adult","metabolic-acidosis",{"fa":41,"en":42},"اسیدوز متابولیک — بزرگسال و کودک ۲ سال به بالا: ۲ تا ۵ mEq\u002Fkg در ۴ تا ۸ ساعت","Metabolic acidosis — adults and children ≥2 y: 2–5 mEq\u002Fkg over 4–8 h",{"minAge":44},{"value":45,"unit":46},2,"year","weightBased",{"perKgPerDay":45,"perKgPerDayMax":49,"dividedDoses":5},5,[51],{"source":34,"section":52},"2.2",{"min":5,"max":5},[55,63],{"text":56,"refs":59},{"fa":57,"en":58},"بر اساس بیکربنات سرم، CO2 کل، pH و وضعیت بالینی. رقیق نشود.","Guided by serum bicarbonate, total CO2, pH and clinical state. Do not dilute.",[60,61],{"source":34,"section":52},{"source":34,"section":62},"2.1",{"text":64,"refs":67},{"fa":65,"en":66},"در ایران بیشتر ویال ۷٫۵٪ و ۸٫۴٪ (حدود ۰٫۹ و ۱ mEq\u002FmL) موجود است (دارویاب)؛ حجم را از mEq و غلظت همان ویال حساب کنید. حجم نمایش‌داده‌شده برای محلول ایزوتونیک ۰٫۱۵ mEq\u002FmL است.","In Iran 7.5% and 8.4% vials (about 0.9 and 1 mEq\u002FmL) are common (Darooyab); compute volume from the mEq dose and that vial’s strength. The volume shown is for the isotonic 0.15 mEq\u002FmL solution.",[68],{"source":69,"section":70},"darooyab-generic","G-2505\u002FSodium-Bicarbonate",{"id":72,"disease":39,"label":73,"population":76,"type":47,"unit":30,"dose":78,"refs":79,"durationDays":81,"notes":82},"child",{"fa":74,"en":75},"اسیدوز متابولیک — زیر ۲ سال و نوزاد: ۱ تا ۲ mEq\u002Fkg در ۴ تا ۸ ساعت","Metabolic acidosis — under 2 y and neonates: 1–2 mEq\u002Fkg over 4–8 h",{"maxAge":77},{"value":45,"unit":46},{"perKgPerDay":5,"perKgPerDayMax":45,"dividedDoses":5},[80],{"source":34,"section":52},{"min":5,"max":5},[83,89],{"text":84,"refs":87},{"fa":85,"en":86},"بولوس یا تزریق سریع نه.","Avoid rapid or bolus administration.",[88],{"source":34,"section":52},{"text":90,"refs":91},{"fa":65,"en":66},[92],{"source":69,"section":70},[94],{"id":95,"severity":96,"text":97,"refs":100},"ci","block",{"fa":98,"en":99},"از دست دادن کلر با استفراغ یا ساکشن معده؛ مصرف دیورتیک‌های ایجادکننده آلکالوز هیپوکلرمیک.","Chloride loss from vomiting or GI suction; diuretics causing hypochloraemic alkalosis.",[101],{"source":34,"section":102},"4",[],[],[],[],{"status":108,"reviewer":109,"date":109},"unverified",null,[111,119],{"regimen":38,"formulation":24,"input":112,"expect":115},{"ageYears":113,"weightKg":114},40,70,{"perDose":116,"mlPerDose":117,"upperPerDose":118},140,933.33,350,{"regimen":72,"formulation":24,"input":120,"expect":123},{"ageMonths":121,"weightKg":122},6,7.5,{"perDose":122,"mlPerDose":124},50,[126],"B05XA02",{"status":128,"forms":129,"refs":206},"registered",[130,134,138,142,146,150,154,158,162,166,170,174,178,182,186,190,194,198,202],{"code":131,"en":132,"fa":133},"08692","BICARBONATE CARTRIGE","بیکربنات کارتریج",{"code":135,"en":136,"fa":137},"01139","BICARBONATE CONCENTRATE 650 G POWDER","پودر بیکربنات ۶۵۰ گرم",{"code":139,"en":140,"fa":141},"06521","BICARBONATE IDEMSA POWDER","پودر بیکربنات ایدمسا",{"code":143,"en":144,"fa":145},"06517","BICARBONATE SMART CART POWDER","پودر بیکربنات سمارت کارت",{"code":147,"en":148,"fa":149},"11409","BICARBONATE SODIUM,ACETYL SALICILIC ACID TAB","قرص بیکربنات سدیم استیل سالیسیلیک اسید",{"code":151,"en":152,"fa":153},"17899","SODIUM BICARBONATE 7.5% 100ML VIAL","ویال سدیم بیکربنات ۷٫۵ درصد ۱۰۰ میلی‌لیتر",{"code":155,"en":156,"fa":157},"20787","SODIUM BICARBONATE 7.5% 25ML VIAL","ویال سدیم بیکربنات ۷٫۵ درصد ۲۵ میلی‌لیتر",{"code":159,"en":160,"fa":161},"17833","SODIUM BICARBONATE 7.5% 50ML BAG","سدیم بیکربنات ۷٫۵ درصد ۵۰ میلی‌لیتر",{"code":163,"en":164,"fa":165},"01140","SODIUM BICARBONATE 7.5% 50ML VIAL","ویال سدیم بیکربنات ۷٫۵ درصد ۵۰ میلی‌لیتر",{"code":167,"en":168,"fa":169},"02353","SODIUM BICARBONATE 8.4% 100ML VIAL","ویال سدیم بیکربنات ۸٫۴ درصد ۱۰۰ میلی‌لیتر",{"code":171,"en":172,"fa":173},"07334","SODIUM BICARBONATE 8.4% 10ML AMP","آمپول سدیم بیکربنات ۸٫۴ درصد ۱۰ میلی‌لیتر",{"code":175,"en":176,"fa":177},"17718","SODIUM BICARBONATE 8.4% 20ML INJ","فرآورده تزریقی سدیم بیکربنات ۸٫۴ درصد ۲۰ میلی‌لیتر",{"code":179,"en":180,"fa":181},"13703","SODIUM BICARBONATE 8.4% 50ML BAG","سدیم بیکربنات ۸٫۴ درصد ۵۰ میلی‌لیتر",{"code":183,"en":184,"fa":185},"07601","SODIUM BICARBONATE 8.4% 50ML VIAL","ویال سدیم بیکربنات ۸٫۴ درصد ۵۰ میلی‌لیتر",{"code":187,"en":188,"fa":189},"17690","SODIUM BICARBONATE CARTRIDGE \u003CITOCHU>  760 CARTRIDGE","کارتریج سدیم بیکربنات \u003C ایتوچو > ۷۶۰",{"code":191,"en":192,"fa":193},"01138","SODIUM BICARBONATE POWDER_BULK","پودر سدیم بیکربنات",{"code":195,"en":196,"fa":197},"01678","SODIUM LACTATE 1\u002F6 MOLAR AMP","آمپول سدیم لاکتات ۱ \u002F ۶ مولار",{"code":199,"en":200,"fa":201},"51939","SODIUM BICARBONATE INJECTION PARENTERAL 8.4 % 10 mL","فرآورده تزریقی سدیم بیکربنات ۸٫۴ درصد ۱۰ میلی‌لیتر",{"code":203,"en":204,"fa":205},"52605","SODIUM BICARBONATE POWDER NOT APPLICABLE","پودر سدیم بیکربنات غیرقابل‌اعمال",[207],{"source":69,"section":70,"url":208},"https:\u002F\u002Fwww.darooyab.ir\u002FG-2505\u002FSodium-Bicarbonate",{"kind":210,"refs":211,"id":214},"NDA",[212],{"source":34,"section":213},"SPL approval \u002F marketing category","NDA218524",[216,219,223,227,230,233],{"kind":217,"url":218,"label":214},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=218524",{"kind":220,"url":221,"label":222},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b50c858a-00c8-4cb2-ad73-8797f19e656d","FDA NaHCO3 1.26%",{"kind":224,"url":225,"label":226},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682001.html","Sodium Bicarbonate",{"kind":224,"url":228,"label":229},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa625025.html","Sodium Bicarbonate Injection",{"kind":231,"url":232,"label":126},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=B05XA02",{"kind":234,"url":208,"label":235},"darooyab","Sodium-Bicarbonate",{"pregnancy":237,"lactation":246,"pediatric":254,"geriatric":262},{"level":238,"text":239,"quote":242,"refs":243},"caution",{"fa":240,"en":241},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published literature over decades of use have not identified a drug associated risk of major birth defects, miscarriage or other adverse maternal or fetal outcomes.",[244],{"source":34,"section":245},"8.1",{"level":238,"text":247,"quote":250,"refs":251},{"fa":248,"en":249},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of sodium bicarbonate in either human or animal milk, the effects on the breast-fed infant or the effects on milk production following administration of sodium bicarbonate injection.",[252],{"source":34,"section":253},"8.2",{"level":238,"text":255,"quote":258,"refs":259},{"fa":256,"en":257},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Sodium bicarbonate injection is indicated in pediatric patients: • To raise plasma pH in pediatric patients with clinically significant metabolic acidosis • To alkalinize the urine in drug poisoning in cases in which urinary drug elimination is enhanced by urinary alkalinization Rapid injection of sodium bicarbonate …",[260],{"source":34,"section":261},"8.4",{"level":238,"text":263,"quote":266,"refs":267},{"fa":264,"en":265},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies of sodium bicarbonate injection did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.",[268],{"source":34,"section":269},"8.5",1792115195707]